Hidenori Matsunaga

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There is a hypothesis that autoimmune abnormalities in neurotransmitter receptors might cause some psychiatric disorders. Using a sensitive radioligand assay, we detected serum autoantibodies to recombinant human muscarinic cholinergic receptor 1 (CHRM1, 34.4%), mu-opioid receptor (OPRM1, 13.1%), 5-hydroxytryptamine receptor 1A (HTR1A, 7.4%), and dopamine(More)
The authors studied antidiuretic hormone (ADH) secretion in schizophrenics on antipsychotic drugs. The mean plasma level of ADH is lower among schizophrenics than among controls at comparable values of plasma osmolality. In regression analysis of the relationship between plasma ADH and plasma osmolality, the slope of the regression line is gentler and the(More)
OBJECTIVE The aim of the present study was to determine the efficacy of ramelteon for treating delirium. METHODS Three patients were prescribed ramelteon for delirium. The severity of the delirium was assessed using the Japanese version of the Memorial Delirium Assessment Scale. RESULTS Memorial Delirium Assessment Scale scores improved after treatment(More)
Forty-two schizophrenics in chronic stages were evaluated using the standard and modified SANS for negative symptoms, and the SADS for positive symptoms. The results of principal components analysis of the two scales were then compared. Analysis of the modified scale scores showed that thought disorder belonged to a unique syndrome orthogonal to both the(More)
The hypothalamo-pituitary-gonadal axis was studied in 12 young women with manic-depressive or psychotic symptoms which obviously fluctuated in association with the menstrual cycle, and also in 36 psychiatric patients with other diagnoses. The hormonal features frequently observed among these 12 cases were elevated basal LH (8 of 12 cases), decreased basal(More)
The authors studied the concentrations of plasma catecholamines in 23 acute schizophrenics, 28 healthy controls, 20 chronic schizophrenics, and 26 otherwise diagnosed psychiatric cases. Blood samples were taken from the consecutively admitted acute schizophrenics before the administration of antipsychotic drugs and catecholamines were assayed with a high(More)
Fifty-six depressive patients underwent a low-dose (0.5-mg) Dexamethasone Suppression Test (DST). Blood samples for cortisol assay were obtained twice on day 2, and the plots of the sum of the two cortisol values formed two groups, consisting, respectively, of suppressors and nonsuppressors. Nineteen (73.1%) of 26 patients with major depressive episodes(More)
OBJECTIVE To highlight the association between posterior reversible encephalopathy syndrome (PRES) and chronic alcoholism. METHODS We present a case report, a review of the literature and a discussion. RESULTS We report on the case of a 51-year-old man with chronic alcoholism, who suddenly developed visual disturbance and confusion. Magnetic resonance(More)
BACKGROUND Results of previous studies and our own preliminary study suggest that the dexamethasone suppression test (DST) using 1 mg of dexamethasone might result in lower sensitivity in Japanese and Asian people with major depressive episodes, when compared to Caucasian people. We investigated the clinical utility of low-dose (0.5 mg) DST in Japanese(More)