Hidenori Matsunaga

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There is a hypothesis that autoimmune abnormalities in neurotransmitter receptors might cause some psychiatric disorders. Using a sensitive radioligand assay, we detected serum autoantibodies to recombinant human muscarinic cholinergic receptor 1 (CHRM1, 34.4%), mu-opioid receptor (OPRM1, 13.1%), 5-hydroxytryptamine receptor 1A (HTR1A, 7.4%), and dopamine(More)
To assess and compare maternal and neonatal outcomes of pregnancy with or without mental disorders. We performed a retrospective cohort study of births at our institution from January 2009 to December 2011, which included all live singleton births during these 3 years. Women emergently transferred to our institution in the middle of their pregnancies were(More)
OBJECTIVE The aim of the present study was to determine the efficacy of ramelteon for treating delirium. METHODS Three patients were prescribed ramelteon for delirium. The severity of the delirium was assessed using the Japanese version of the Memorial Delirium Assessment Scale. RESULTS Memorial Delirium Assessment Scale scores improved after treatment(More)
OBJECTIVE To highlight the association between posterior reversible encephalopathy syndrome (PRES) and chronic alcoholism. METHODS We present a case report, a review of the literature and a discussion. RESULTS We report on the case of a 51-year-old man with chronic alcoholism, who suddenly developed visual disturbance and confusion. Magnetic resonance(More)
BACKGROUND Borna disease virus (BDV) infection of humans has not been widely accepted due to the low titer of the antibody and lack of reliable diagnostic tools. OBJECTIVES To examine exposure to BDV or a related virus in Japanese psychiatric and general population by detecting the specific IgG, IgM, and IgA. STUDY DESIGN Sera from 304 psychiatric and(More)
Using a radioligand assay, which preserves the natural form of the antigen, antibodies against Borna disease virus nucleoprotein and phosphoprotein were detected in 11 and 19 sera of 171 psychiatric patients, respectively. Compared with results by Western blotting, three and nine sera were concordantly positive, respectively. The four sera showing the(More)
BACKGROUND A history of psychiatric disorders is a high risk for suicide. The present study compared the clinical features of psychiatric patients in Japan who attempted suicide by jumping from a height and those who attempted suicide by self-stabbing. METHODS We compared two groups of suicide attempters who were hospitalized for both physical and(More)
WHAT IS KNOWN AND OBJECTIVE Long-acting formulations are an important therapeutic option for non-adherent patients with schizophrenia. There is a commonly held view that management of long-acting formulation-induced side effects is difficult. CASE DESCRIPTION We present a patient with schizophrenia who developed acute and persistent extrapyramidal(More)
We present the case of a 47-year-old man with schizophrenia who developed acute and persistent circulatory failure after receiving injections of paliperidone palmitate. We measured blood concentrations of paliperidone and performed resection of hip tissues, where paliperidone palmitate was suspected to be present, in order to reduce the side effects.(More)