Hidenobu Takahashi

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Earlier studies have demonstrated that an excitatory cardiovascular response can be produced through activation of a spinal cholinergic system in rats. The present study was performed to determine whether this excitatory cardiovascular response was elicited through cholinergic potentiation of a descending spinal sympathoexcitatory pathway. Application of(More)
The neurotoxic effects of aluminum have been widely reported but the mechanism of action and detoxification is poorly understood. To investigate the toxic potential of aluminum, we found it necessary to detail the behavior of absorbed aluminum in brain. The aim of this study was to clarify the distribution of aluminum in the brain. Rats were exposed to(More)
A novel organogermanium compound, Ge-132, carboxyethylgermanium sesquioxide, showed enhancement of 0.5 mg/kg morphine analgesia in both administration routes of oral administration (p.o.) and intraperitoneal injection (i.p.) in the Tail-Flick test, and the effect was completely abolished by 0.5 mg/kg Naloxone, stereospecific opiate antagonist. Ge-132 alone,(More)
OBJECTIVE The present study aimed to clarify the structural recovery, and to compare the time course of morphological changes in trabeculae and the process of bone mass change in rat tibiae following temporary immobilization of hind limb by sciatic neurectomy or nerve freezing. METHODS In 11-week-old male Fischer 344 rats, 4-5 mm of the sciatic nerve was(More)
The relationship between enkephalinase inhibition by thiorphan in vivo and analgesic activity in nociceptive tests was studied. The analgesic activity of thiorphan in various nociceptive tests was compared with that of a narcotic analgesic, morphine and antipyretic analgesic, antipyrine. Tail-flick test revealed that thiorphan applied(More)
BACKGROUND Numerous techniques and materials are available for increasing the dorsal height and length of the nose. Microautologous fat transplantation (MAFT) may be an appropriate strategy for augmentation rhinoplasty. OBJECTIVES The authors sought to determine the long-term results of MAFT with the so-called one-third maneuver in Asian patients who(More)
The patient, a 63-year-old man, experienced the subacute onset of chorea, for which his family doctor prescribed oral haloperidol. However, the involuntary movements gradually worsened, and the patient was referred and admitted. High-signal lesions were seen in the caudate nucleus, putamen and globus pallidus bilaterally on MRI T2-weighted and FLAIR images.(More)
The purpose of this study was to examine the relationship between spinal cholinergic pressor neurons and a somatosympathetic reflex response in rats. Intrathecal (IT) injection of the cholinesterase inhibitor, neostigmine (NEO), produced marked pressor and tachycardic responses without any changes in respiratory parameters. On the other hand, stimulation of(More)
This study was performed to help elucidate the role of spinal cholinergic neurons in cardiorespiratory function by selective activation of spinal or medullary cholinergic systems in anesthetized rats. A selective site of action of cholinergic drugs on the spinal cord was obtained by refining the method of intrathecal (i.t.) drug injection to localize drug(More)
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