Hideki Hayakawa

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Parkinson’s disease (PD) is a neurodegenerative disease characterized by selective degeneration of dopaminergic neurons in the substantia nigra (SN). The familial form of PD, PARK2, is caused by mutations in the parkin gene. parkin-knockout mouse models show some abnormalities, but they do not fully recapitulate the pathophysiology of human PARK2. Here, we(More)
The aim was to identify the amyloid beta (Aβ) deposition by positron emission tomography (PET) imaging with the 18F-labeled Pittsburgh compound B (PIB) derivative [18F]flutemetamol (FMM) across a spectrum of Alzheimer’s disease (AD) and to compare Aβ deposition between [18F]FMM and [11C]PIB PET imaging. The study included 36 patients with AD, 68 subjects(More)
The present study was designed to elucidate the inflammatory and apoptotic mechanisms of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in a model of Parkinson's disease. Our results showed that mutant mice lacking the caspase-11 gene were significantly more resistant to the effects of acute treatment with MPTP than their(More)
α-Synuclein (α-syn) is a key protein in Parkinson's disease (PD), and its abnormal accumulation is implicated only not in the loss of dopaminergic neurons in the substantia nigra but also in impairment of olfactory bulb (OB) in PD. Olfactory dysfunction could arise from these OB changes as an early symptom in PD. We reported previously the impairment of(More)
Loss-of-function mutations in the ubiquitin ligase parkin are the major cause of recessively inherited early-onset Parkinson disease (PD). Impairment of parkin activity caused by nitrosative or dopamine-related modifications may also be responsible for the loss of dopaminergic (DA) neurons in sporadic PD. Previous studies have shown that viral(More)
The I93M mutation in ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) was reported in one German family with autosomal dominant Parkinson's disease (PD). The causative role of the mutation has, however, been questioned. We generated transgenic (Tg) mice carrying human UCHL1 under control of the PDGF-B promoter; two independent lines were generated with the(More)
Hermatypic (or reef-building) corals live in obligatory mutualistic symbiosis with the symbiotic dinoflagellates Symbiodinium spp. (generally known as zooxanthellae). In an attempt to establish a model symbiosis system consisting of a coral host and a monoclonal population of zooxanthellae, infectivity of five cultured Symbiodinium cell lines was tested on(More)
The reef-building (or hermatypic) coral Galaxea fascicularis (Anthozoa, Hexacorallia, Scleractinia) has an annual reproductive cycle. Females of G. fascicularis release packages (or ;bundles') of eggs for external fertilization, whereas male individuals form bundles consisting of sperm and infertile ;pseudo-eggs' that are thought to confer buoyancy to the(More)
Yasuto Nakata,1,4 Toru Yasuda,1,4,5 Masahiro Fukaya,2 Saori Yamamori,3 Makoto Itakura,3 Tomoko Nihira,1,4 Hideki Hayakawa,1,4 Aya Kawanami,1 Masakazu Kataoka,6 Makiko Nagai,1 Hiroyuki Sakagami,2 Masami Takahashi,3 Yoshikuni Mizuno,4 and Hideki Mochizuki1,4,5 Departments of 1Neurology, 2Anatomy, and 3Biochemistry, and 4Division of Neuroregenerative Medicine,(More)