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We present a distributed algorithm for converging autonomous mobile robots with limited visibility toward a single point. Each robot is an omnidirectional mobile processor that repeatedly: 1) observes the relative positions of those robots that are visible; 2) computes its new position based on the observation using the given algorithm; 3) moves to that(More)
Half a century ago, thalidomide was widely prescribed to pregnant women as a sedative but was found to be teratogenic, causing multiple birth defects. Today, thalidomide is still used in the treatment of leprosy and multiple myeloma, although how it causes limb malformation and other developmental defects is unknown. Here, we identified cereblon (CRBN) as a(More)
Islet-1 (Isl1) is a member of the Isl1 family of LIM-homeodomain transcription factors (LIM-HD) that is expressed in a defined subset of motor and sensory neurons during vertebrate embryogenesis. To investigate how this specific expression of isl1 is regulated, we searched for enhancers of the isl1 gene that are conserved in vertebrate evolution. Initially,(More)
We discuss fundamental formation and agreement problems for autonomous, synchronous robots with limited visibility. Each robots is a mobile processor that, at each discrete time instant, observes the relative positions of those robots that are within distance V of itself, computes its new position using the given algorithm, and then moves to that position.(More)
The telencephalon shows the greatest degree of size variation in the vertebrate brain. Understanding the genetic cascade that regulates telencephalon growth is crucial to our understanding of how evolution of the normal human brain has supported such a variation in size. Here, we present a simple and quick approach to analyze this cascade that combines(More)
Cereblon (CRBN), the molecular target of lenalidomide and pomalidomide, is a substrate receptor of the cullin ring E3 ubiquitin ligase complex, CRL4(CRBN) . T cell co-stimulation by lenalidomide or pomalidomide is cereblon dependent: however, the CRL4(CRBN) substrates responsible for T cell co-stimulation have yet to be identified. Here we demonstrate that(More)
The Cul4-Rbx1-DDB1-Cereblon E3 ubiquitin ligase complex is the target of thalidomide, lenalidomide and pomalidomide, therapeutically important drugs for multiple myeloma and other B-cell malignancies. These drugs directly bind Cereblon (CRBN) and promote the recruitment of substrates Ikaros (IKZF1) and Aiolos (IKZF3) to the E3 complex, thus leading to(More)
Fifty years ago, prescription of the sedative thalidomide caused a worldwide epidemic of multiple birth defects. The drug is now used in the treatment of leprosy and multiple myeloma. However, its use is limited due to its potent teratogenic activity. The mechanism by which thalidomide causes limb malformations and other developmental defects is a(More)
Recent mobile processors are required to exhibit both low-energy consumption and high performance. To satisfy these requirements, dynamic voltage scaling (DVS) is currently employed. However, its effectiveness will be limited in the future because of shrinking the variable supply voltage range. As an alternative, we previously proposed pipeline stage(More)
It is difficult to improve the single-thread performance of a processor in memory-intensive programs because processors have hit the memory wall, i.e., the large speed discrepancy between the processors and the main memory. Exploiting memory-level parallelism (MLP) is an effective way to overcome this problem. One scheme for exploiting MLP is aggressive(More)