Hideho Honda

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1. K(+)-stimulated 45Ca2+ uptake by synaptosomes was measured with respect to the strain differences between Sprague-Dawley (SD), Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). 2. 45Ca2+ uptake by synaptosomes isolated from cerebral cortex of SD, WKY and SHR was measured at 15, 30, 60, 120 and 240 sec time periods. 3. The sequence of both the(More)
We have observed two cases with marked reading and writing deficits, in which speech and oral comprehension were generally intact. Detailed symptomatological study was performed on these cases, and the lesions were examined organically (X-ray computed tomography [X-ray CT], magnetic resonance imaging [MRI] and functionally (positron emission tomography(More)
Gastric fundic gland polyps (FGPs) are common non-adenomatous gastric polyps arising from normal fundic mucosa without Helicobacter pylori (H. pylori) infection. Although systemic FGPs associated with familial adenomatous polyposis (FAP) often have dysplasia, there are few reports of dysplasia occurring in sporadic FGPs, especially when detected by(More)
Voltage-dependent 45Ca2+ uptake into rat whole brain P1 (nonsynaptosomal) and P2 (synaptosomal) fractions was measured after 60-s KCl-stimulated depolarization to investigate possible inhibitory effects of Ca2+ antagonists, nitrendipine, diltiazem, verapamil and ifenprodil tartrate. All drugs (10(-5)M) had little influence on 45Ca2+ uptake by whole brain P1(More)
In our earlier report [Shibuya et al. in press], we demonstrated the partial mechanism of the synergism between ifenprodil tartrate and calcium hopantenate on cardiovascular diseases. The mechanisms of the synergistic effects in the basilar and vertebral arteries were further studied in this paper using our described methods. Ifenprodil tartrate produced a(More)
Contractile responses of strips of the prostatic end of vasa deferentia isolated from streptozotocin-treated diabetic rats were investigated with five agonists. Agonists induced similar biphasic responses in vasa deferentia from diabetic and age-matched control rats six to seven weeks after streptozotocin. Twitches were observed superimposed on contractions(More)
We studied the response time of drugs in relation to the feedback mechanism in animals. The time from drug administration to onset of loss and recovery of righting reflex or death by hexobarbital in mice were measured at several dose levels and it was demonstrate that in every case the time (t)- response rate (R) function could be expressed as: (formula:(More)
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