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Genome sequencing and analysis of Aspergillus oryzae

• Masayuki Machida, Kiyoshi Asai, +61 authors Hisashi Kikuchi
• Nature
• 2005

The genome of Aspergillus oryzae, a fungus important for the production of traditional fermented foods and beverages in Japan, has been sequenced. The ability to secrete large amounts of proteins and… (More)

The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular…

• Toyohide Shinkawa, Kazuyasu Nakamura, +9 authors Kenya Shitara
• The Journal of biological chemistry
• 2003

An anti-human interleukin 5 receptor (hIL-5R) humanized immunoglobulin G1 (IgG1) and an anti-CD20 chimeric IgG1 produced by rat hybridoma YB2/0 cell lines showed more than 50-fold higher… (More)

Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein.

• Takako Shiraki-Iida, Hideyuki Aizawa, +6 authors Yuko Nabeshima
• FEBS letters
• 1998

We previously established a novel mouse model for human aging and identified the genetic foundation responsible for it. A defect in expression of a novel gene, termed klotho (kl), leads to a syndrome… (More)

Parathyroid hormone activation of the 25-hydroxyvitamin D3-1alpha-hydroxylase gene promoter.

• H L Brenza, Christine Kimmel-Jehan, +5 authors Hector F DeLuca
• Proceedings of the National Academy of Sciences…
• 1998

The DNA flanking the 5' sequence of the mouse 1alpha-hydroxylase gene has been cloned and sequenced. A TATA box has been located at -30 bp and aCCAAT box has been located at -79 bp. The gene's… (More)

Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys.

• Yu Kato, Emi Arakawa, +14 authors Yo-ichi Nabeshima
• Biochemical and biophysical research…
• 2000

A novel gene, klotho (kl), which is involved in the development of a syndrome resembling human aging in mice, was recently identified. The kl gene encodes a single-pass membrane protein whose… (More)

A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils.

• Akeo Shinkai, Hajime Yoshisue, +10 authors Tatsunari Nishi
• Journal of immunology
• 1999

IL-4 has been shown to be involved in the accumulation of leukocytes, especially eosinophils, at sites of inflammation by acting on vascular endothelial cells. To identify novel molecules involved in… (More)

Cloning and expression of rat 25-hydroxyvitamin D3-1alpha-hydroxylase cDNA.

• Toshimasa Shinki, Hideo Shimada, +5 authors Toshio Suda
• Proceedings of the National Academy of Sciences…
• 1997

A full-length cDNA for the rat kidney mitochondrial cytochrome P450 mixed function oxidase, 25-hydroxyvitamin D3-1alpha-hydroxylase (P4501alpha), was cloned from a vitamin D-deficient rat kidney cDNA… (More)

A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models

• Hiroyuki Ishida, Taisuke Nakata, +10 authors Shiro Akinaga
• Breast Cancer Research and Treatment
• 2007

We screened a series of 17β-(N-alkylcarbamoyl)-estra-1,3,5(10)trine-3-O-sulfamate derivatives, and describe here a potent and selective steroid sulfatase (STS) inhibitor with antitumor effects in… (More)

Mapping of the sites involved in ligand association and dissociation at the extracellular domain of the kinase insert domain-containing receptor for vascular endothelial growth factor.

• Akeo Shinkai, Mie Ito, Hideharu Anazawa, Seiichi Yamaguchi, Kenya Shitara, Masabumi Shibuya
• The Journal of biological chemistry
• 1998

The kinase insert domain-containing receptor (KDR) for vascular endothelial growth factor (VEGF) has been shown to be involved in vasculogenesis and angiogenesis. This receptor is characterized by… (More)

Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase.

• Toshiaki Monkawa, Takeshi Yoshida, +6 authors Takao Saruta
• Biochemical and biophysical research…
• 1997

The 25-hydroxyvitamin D3 1 alpha-hydroxylase (1 alpha-hydroxylase) is a cytochrome P450 enzyme that catalyzes the conversion of 25-hydroxyvitamin D3 to 1 alpha,25-dihydroxyvitamin D3. This enzyme… (More)

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