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The phosphatidylinositol-3-kinase (PI3K) pathway is commonly hyperactivated in cancer. One mechanism by which this occurs is by silencing of the phosphatase and tensin homolog (PTEN), a tumor suppressor and major antagonist of the pathway, through genetic, epigenetic or posttranscriptional mechanisms. Here, we used an unbiased siRNA screen in non-small-cell(More)
Recent preliminary studies reported the in vitro tumor-promoting effects of long non-coding RNA urothelial carcinoma associated 1 (UCA1) in colorectal cancer (CRC). However, the in vivo functions and molecular mechanism of UCA1 in CRC remain unclear. Therefore, we investigated the detailed role and mechanism of UCA1 in CRC. We found that UCA1 was(More)
Evidence for impacts of environmental changes on belowground net primary production (BNPP) from long-term experiments is rather scarce. We aimed to understand how long-term changes in water and nitrogen availability affect production and vertical allocation of roots in semi-arid grasslands and its consequence on carbon (C) and nitrogen (N) cycles. We(More)
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