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Interleukin-32α inactivates JAK2/STAT3 signaling and reverses interleukin-6-induced epithelial–mesenchymal transition, invasion, and metastasis in pancreatic cancer cells
It is shown that reversion of epithelial–mesenchymal transition, inhibition of invasiveness and metastasis, and activation of the JAK2/STAT3 signaling pathway could be achieved through the application of exogenous IL-32α. Expand
Promotion of Metastasis-associated Gene Expression in Survived PANC-1 Cells Following Trichostatin A Treatment.
TSA can induce apoptosis of pancreatic cancer cells and the up-regulation of metastasis-related genes and the activation of the Notch pathway in the survived PANC-1 cells may be associated with a too-low level of TSA or resistance to TSA. Expand
Design, synthesis, and biological evaluation of novel EF24 and EF31 analogs as potential IκB kinase β inhibitors for the treatment of pancreatic cancer
D6 may be a promising therapeutic agent for PC treatment and it provides a structural lead for the design of novel IKKβ inhibitors, as well as effectively inducing cancer cell apoptosis. Expand
LncRNA SOCS2-AS1 inhibits progression and metastasis of colorectal cancer through stabilizing SOCS2 and sponging miR-1264
A novel regulatory loop in which SOCS2-AS1/miR-1264/SOCS2 axis suppresses CRC progression is identified, which is associated with a poor prognosis in patients with CRC. Expand
Design , synthesis , and biological evaluation of novel EF 24 and EF 31 analogs as potential i κ B kinase β inhibitors for the treatment of pancreatic cancer
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