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Journals and Conferences
To examine the effects on bitterweed toxicity of dietary factors known to increase thiol concentrations in the body, 36 lambs were fed one of the following diets (12 lambs/diet) for a minimum of 9 days prior to bitterweed administration: diet 1, 10% crude protein; diet 2, 20% crude protein, 0.5% methionine, 0.5% sodium sulfate, and 1,102 IU of vitamin E/kg;… (More)
Tissue residue levels of gossypol enantiomers in cottonseed-fed and lethally intoxicated lambs were determined by the high-performance liquid chromatography-ultraviolet detection method. Gossypol was derivatized with (+)-2-amino-1-propanol and separated with a reversed-phase C18 column and the elution of analytes was monitored at 254 nm. The highest residue… (More)
1. Constitutive and Aroclor 1254-induced hepatic glutathione (GSH) S-transferases, GSH peroxidase and GSH reductase activities were determined in 12 strains of 8-10 week-old inbred male mice. 2. The constitutive GSH S-transferase activity varied from 2.5 (SJL/JCR) to 8.9 (C57BL/6N) mumol/min/mg protein and the corresponding values for the Aroclor… (More)
The acute oral toxicity of hymenoxon is dose-dependent, and the clinical signs and pathologic lesions are qualitatively identical to those of animals fed whole bitterweed. There was no synergistic effect when sheep were fed hymenoxon with hymenolane.
Administration of butylated hydroxyanisole (BHA), ethoxyquin (EQ), and disulfiram (DSF) in the diet for 7 days reduced the acute toxicity of pyrrolizidine alkaloids isolated from Senecio longilobus. The LD50 values of the BHA- and EQ-fed mice were about twofold of the controls but the protective effect of DSF was inferior to that of either BHA or EQ.
L-Cysteine was given IV at dosages of 34.5, 48.8, 69.0, 97.6, or 138.0 mg/kg of body weight to groups of sheep previously treated (10.6 minutes) intraperitoneally with an LD92 of hymenoxon (12.8 mg/kg). L-Cysteine at dosages of 69.0, 97.6, and 138.0 mg/kg significantly increased survival rate 8.4-, 10-, and 12.5-fold, respectively, over that of… (More)
Ethoxyquin (EQ, 1,2-dihydro-6-ethoxy-2,2,4-trimethylquinoline) was purified and converted to a crystalline, stable ethoxyquin hydrochloride (EQ-HCl). The readily available (technical grade) oily EQ reacted with concentrated hydrochloric acid (HCl) and precipitated as a crystalline salt (EQ-HCl) in acetone, leaving most of the impurities in solution. The… (More)