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Identification of a RNA-seq-based signature to improve prognostics for uterine sarcoma.
TLDR
A novel 6-gene signature and nomogram which could improve prognosis prediction in patients with US patients was established and indicated that the signature can play a vital role in cancer-related biological processes. Expand
Sec62 promotes early recurrence of hepatocellular carcinoma through activating integrinα/CAV1 signalling
TLDR
Multivariate analysis revealed that Sec62 was an independent prognostic factor for early recurrence in postoperative HCC patients and promotes HCC metastasis through integrinα/CAV1 signalling and might be an attractive drug target for combating HCC postsurgical recurrence. Expand
CFHR3 is a potential novel biomarker for hepatocellular carcinoma
TLDR
Gene set enrichment analysis implied that the low CFHR3 expression phenotype was significantly enriched in critical biological functions and pathways and was associated with tumorigenesis, such as regulation of cell activation cycle, and the WNT and NOTCH signal pathway. Expand
Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis
TLDR
PLR may be a significant biomarker in the prognosis of HCC in different BCLC stages and correlation between PLR and event occurrence was related to poor clinical event occurrence only among BclC-C patients, though obvious heterogeneity was observed in all different B CLC stages. Expand
Identification of a nomogram based on long non-coding RNA to improve prognosis prediction of esophageal squamous cell carcinoma
TLDR
A nomogram based on the lncRNAs signature, age, grade and stage was developed and showed good accuracy for predicting 1-, 3- and 5-year survival probability of ESCC patients and could be practical and reliable prognostic tools for esophageal squamous cell carcinoma. Expand
Transarterial chemoembolization combined with Jie-du granule preparation improves the survival outcomes of patients with unresectable hepatocellular carcinoma
TLDR
It is shown that patients with unresectable HCC who were administered TACE-JD survived significantly longer compared with those administer TACE or Tace-SOR, and independent predictors of OS were treatment allocation, Child-Pugh class large tumor, albumin and extrahepatic metastasis. Expand
Comparable effects of Jiedu Granule, a compound Chinese herbal medicine, and sorafenib for advanced hepatocellular carcinoma: A prospective multicenter cohort study.
TLDR
Compared to sorafenib, JD Granule was more cost-effective and caused fewer AEs for the treatment of Chinese patients with advanced HCC. Expand
Prognostic Power of a Chaperonin Containing TCP-1 Subunit Genes Panel for Hepatocellular Carcinoma
TLDR
A novel three-gene signature and nomogram from CCT subunit genes are built to predict the prognosis of hepatocellular carcinoma, which may support the medical decision for HCC therapy. Expand
m6A RNA Methylation Regulators Elicit Malignant Progression and Predict Clinical Outcome in Hepatocellular Carcinoma
TLDR
The vital role of m6A RNA methylation regulators in the initial presentation and progression of HCC is demonstrated and a nomogram which would predict the clinical outcome and provide a basis for individualized therapy is constructed. Expand
Sec62 promotes pro-angiogenesis of hepatocellular carcinoma cells under hypoxia.
TLDR
DeGs, such as serine protease inhibitor E (SERPINE) and tumor necrosis factor receptor superfamily, member 11B (TNFRSF11B), were not only identified as the lead genes of these enriched pathways, but were also found to be closely related to Sec62. Expand
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