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OBJECTIVE To obtain normal M mode (one dimensional) echocardiographic values in a substantial sample of normal infants and children. DESIGN Data were obtained over three years from a single centre in central Europe. PATIENTS 2036 healthy infants and children aged one day to 18 years. METHODS In line with recommendations for standardising measurements(More)
Aufgabe des Arztes ist es, unter Beachtung des Selbstbestimmungsrechtes des Patienten Leben zu erhalten, Gesundheit zu schützen und wiederherzustellen sowie Leiden zu lindern und Sterbenden bis zum Tod beizustehen. Der Intensivmedizin stehen dazu immer mehr und differenziertere Möglichkeiten zur Verfügung. Der Arzt hat im Rahmen seiner professionellen(More)
The aim of this study was to assess the physical performance in long-term survivors of acute leukaemia in childhood and to evaluate the effects of anthracycline therapy. Electrocardiography, echocardiography and spiroergometry were carried out on 56 patients aged 9–28 years, of whom 44 patients had been treated with 15–483 mg/m2 doxorubicin (or equivalent).(More)
After describing the particular features of the fetal circulation, changes in the pattern of blood flow at the time of birth and during early neonatal life are explained. From animal studies it is wellknown that during the first hours and weeks after birth newborns are characterized by an extremely high cardiac output due to high metabolic demands. In order(More)
We investigated the effects of dobutamine therapy on myocardial function in premature infants. Left ventricular performance was assessed by measuring left ventricular systolic time intervals: rate-corrected pre-ejection period (PEPI), rate-corrected left ventricular ejection time (LVETI), and pre-ejection period to left ventricular ejection time ratio(More)
The effect of dobutamine, a synthetic catecholamine, was studied in 12 patients aged one day to 14 years with low cardiac output syndromes. After initial stabilization of the patients dobutamine was administered by continuous infusion in a dosage of 7.5 or 10 μg/kg/min. Heart rate, cardiac output (using thermodilution technique and/or pulse contour method),(More)
In a 13-year girl with head injury the hemodynamic parameters during 2 episodes of intraventricular hemorrhage were monitored. There were hyperdynamic values for heart rate, Cardiac output, mean arterial and pulmonary artery pressures, systemic vascular and pulmonary vascular resistances. It is likely that centrogenic, sympathico-adrenergic reactions are(More)
OBJECTIVE The purpose of this study was to assess the value of biometric lung measurements for the prediction of severe fetal pulmonary hypoplasia in congenital diaphragmatic hernia and to determine whether a correlation between lung measurements and autopsy findings or neonatal outcome could be established. DESIGN Prospective study, between 1991 and(More)
The efficacy of Nifedipine (N) as an antihypertensive drug was assessed in 4 children aged 6-12 years with acute severe hypertension. In one child with a hypertensive encephalopathy N 10 mg administered sublingually in addition to other antihypertensive drugs caused a prompt fall in blood pressure followed by a rapid clinical improvement. In the other 3(More)
Systemic candidiasis developed in a seven-week-old premature baby after 6 weeks treatment with antibiotics for suspected septicemia. At that time the echocardiogram showed a dense layer of echoes posteriorly to the anterior tricuspid leaflet during atrial systole. The diagnosis of Candida endocarditis with vegetations on the tricuspid valve and with right(More)