Herwig Schuler

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Inosine monophosphate dehydrogenase (IMPDH) and guanosine monophosphate reductase (GMPR) belong to the same structural family, share a common set of catalytic residues and bind the same ligands. The structural and mechanistic features that determine reaction outcome in the IMPDH and GMPR family have not been identified. Here we show that the GMPR reaction(More)
The molecular-beam magnetic-resonance method has been applied to study the radiofrequency spectra of the molecules D2 and HD, in the state J=1.All the measurements were made in applied magnetic fields large enough to decouple the angular momentum vectors concerned. The spectrum of D2 for the transitions mq — — ~1 consists of six lines as in H2. The HD(More)
A combination of fluorescence polarization (FPZ) and nuclear magnetic resonance (NMR) techniques have revealed that ethanol has diverse and domain dependent effects on membrane order. Under some conditions, in the more superficial membrane domains, ethanol actually orders rather disorders membrane structure. Using 1H-NMR we have examined in synaptic(More)
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