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Incubation of a crude synaptosomal fraction from rat striatum with GBR 12783 at 37 degrees C produced an inhibition of the specific uptake of [3H]dopamine that increased with time. The inhibition increased when GBR 12783 was present during preincubation and incubation (IC50 = 1.85+/-0.1 nM) instead of incubation alone (IC50 = 25+/-3.5 nM). Time-course(More)
The aim of this study was to evaluate the influence of primidone (PRM) nanoencapsulation on its metabolism. Suspensions of PRM powder and PRM-loaded poly-epsilon-caprolactone nanocapsules were administered orally in the same way to rats. Primidone-loaded poly-epsilon-caprolactone nanocapsules were prepared according to the interfacial deposition technique.(More)
e15053 Background: Androgen-deprivation therapy (ADT) is associated with the metabolic syndrome and cardiovascular disease (unfavorable lipid profile, obesity and insulin resistance). The Mediterrean Diet (MedD), a diet high in olive oil, fruits, vegetables, nuts and whole grains, may reduce the risk of the metabolic syndrome. An 8-week MedD program was(More)
Acoustic micropropulsors present great potential for microfluidic applications. The propulsion is based on encapsulated 20 μm bubbles excited by a contacless ultrasonic transducer. The vibrating bubbles then generate a powerful streaming flow, with speeds 1-100 mm s-1 in water, through the action of viscous stresses. In this paper we introduce a full(More)
34 accounts of medicines found in the rolls of "Maîtrise Notre-Dame" of Rouen were studied. Data concerning clysters, ptysans, violet sirup, theriac, marsh-mallow paste and physic were particularly collected. Their interpretation showed a relative stability of the market prices of drugs and medicines, expressed in pounds, during a century and a half, in(More)
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