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Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates.
We have refined a series of isomorphous crystal structures of the Escherichia coli DNA mismatch repair enzyme MutS in complex with G:T, A:A, C:A and G:G mismatches and also with a single unpairedExpand
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The alternating ATPase domains of MutS control DNA mismatch repair
DNA mismatch repair is an essential safeguard of genomic integrity by removing base mispairings that may arise from DNA polymerase errors or from homologous recombination between DNA strands. InExpand
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ATP Increases the Affinity between MutS ATPase Domains
MutS is the key protein of the Escherichia coli DNA mismatch repair system. It recognizes mispaired and unpaired bases and has intrinsic ATPase activity. ATP binding after mismatch recognition byExpand
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MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA
To avoid mutations in the genome, DNA replication is generally followed by DNA mismatch repair (MMR). MMR starts when a MutS homolog recognizes a mismatch and undergoes an ATP-dependentExpand
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Dual role of MutS glutamate 38 in DNA mismatch discrimination and in the authorization of repair
MutS plays a critical role in DNA mismatch repair in Escherichia coli by binding to mismatches and initiating repair in an ATP‐dependent manner. Mutational analysis of a highly conserved glutamate,Expand
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Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS
The DNA mismatch repair protein MutS recognizes mispaired bases in DNA and initiates repair in an ATP-dependent manner. Understanding of the allosteric coupling between DNA mismatch recognition andExpand
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Magnesium Coordination Controls the Molecular Switch Function of DNA Mismatch Repair Protein MutS*
The DNA mismatch repair protein MutS acts as a molecular switch. It toggles between ADP and ATP states and is regulated by mismatched DNA. This is analogous to G-protein switches and the regulationExpand
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Mismatch repair inhibits homeologous recombination via coordinated directional unwinding of trapped DNA structures.
Homeologous recombination between divergent DNA sequences is inhibited by DNA mismatch repair. In Escherichia coli, MutS and MutL respond to DNA mismatches within recombination intermediates andExpand
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USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A
BRCA1-BARD1-catalyzed ubiquitination of histone H2A is an important regulator of the DNA damage response, priming chromatin for repair by homologous recombination. However, no specificExpand
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alpha-D-galactosyltransferase activity in calf thymus. A high-resolution 1H-NMR study.
In calf thymus an alpha-D-galactosyltransferase activity has been detected that transfers galactosyl residues from UDP-galactose to suitable acceptors having galactose at the non-reducing terminus.Expand
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