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  • Chimed Jansen, Huanchen Wang, +8 authors Rob Leurs
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2013 (First Publication: 1 March 2013)
  • Trypanosoma brucei cyclic nucleotide phosphodiesterase B1 (TbrPDEB1) and TbrPDEB2 have recently been validated as new therapeutic targets for human African trypanosomiasis by both genetic andExpand
  • Jens Selige, Hermann Tenor, Armin Hatzelmann, Torsten Dunkern
  • Biology, Medicine
  • Journal of cellular physiology
  • 2010 (First Publication: 1 May 2010)
  • Interleukin-1beta (IL-1beta) and basic fibroblast growth factor (bFGF) are important regulators of proliferation, and their expression is increased in lungs of patients with asthma, idiopathicExpand
  • Tatiana Victoni, Florence Gléonnec, +5 authors Elisabeth Boichot
  • Medicine
  • PloS one
  • 2014 (First Publication: 8 January 2014)
  • Cigarette smoke is a major cause of chronic obstructive pulmonary disease (COPD). Airway epithelial cells and macrophages are the first defense cells against cigarette smoke and these cells are anExpand
  • Antoni R Blaazer, Abhimanyu K. Singh, +24 authors Rob Leurs
  • Medicine, Chemistry
  • Journal of medicinal chemistry
  • 2018 (First Publication: 19 April 2018)
  • Several trypanosomatid cyclic nucleotide phosphodiesterases (PDEs) possess a unique, parasite-specific cavity near the ligand-binding region that is referred to as the P-pocket. One of these enzymes,Expand