Hermann Mellinghoff

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BACKGROUND Several drugs influence the time course of neuromuscular block during general anaesthesia. OBJECTIVE To evaluate the effect of a single dose of dexamethasone 8 mg on the time course of a rocuronium-induced neuromuscular block. DESIGN A randomised controlled, unblinded, monocentre trial. SETTING Kreiskrankenhaus Dormagen, Dormagen, Germany.(More)
Einführung: In einer Übersicht werden die aktuellen Entwicklungen in der Messung der neuromuskulären Blockade sowie die neuen Muskelrelaxanzien dargestellt. Muskelrelaxanzien: Von den seit 1995/96 in Deutschland neu zugelassenen Muskelrelaxanzien Rocuronium, Cisatracurium und Mivacurium, bietet Rocuronium die kürzeste Anschlagszeit bei ansonsten gleichem(More)
OBJECTIVE To assess clinical efficacy of controlled-release oxycodone (CRO) 20 mg on a 12-h dosing schedule in this prospective, randomised, placebo-controlled, double-blinded study of 40 ASA physical status I-III women undergoing breast surgery for cancer. RESEARCH DESIGN AND METHODS General anaesthesia using remifentanil and propofol was performed for(More)
Cisatracurium is a new nondepolarizing muscle relaxant. In patients randomized to receive either cisatracurium (n = 40) or atracurium (n = 20) we compared the time course of neuromuscular block. The initial bolus dose of cisatracurium was 0.1 mg/kg, that of atracurium 0.5 mg/kg. Neuromuscular block, maintained with an infusion of either drug, was reversed(More)
INTRODUCTION Recent developments in both the quantitative evaluation of neuromuscular blockade and new muscle relaxants are reviewed. With respect to nerve stimulation, neuromuscular recording, and definition of parameters, the results of the 1994 Copenhagen International Consensus Conference are highlighted. Future clinical studies should adhere to these(More)
Cisatracurium (51W89) is one of the ten stereoisomers of atracurium, accounting for about 15% of the racemate. The ED95 of cisatracurium was determined to be about 50 micrograms/kg (cation, molecular weight 929), while the ED95 of atracurium (besylate salt, molecular weight 1245) was 250 micrograms/kg. Thus, on a molar basis in adult patients, cisatracurium(More)
The purpose of this study was to compare the characteristics of recovery from neuromuscular blockade after either atracurium or vecuronium given by intravenous infusion or by repeated injection. Four groups of 10 patients each were studied during nitrous oxide narcotic anesthesia. An initial intravenous dose of 2 x ED95 of either muscle relaxant was(More)
We have assessed intubating conditions provided by rapacuronium (Org 9487) and succinylcholine after rapid sequence induction of anaesthesia in adult patients undergoing elective surgery. We studied 335 patients, ASA I and II, in five centres. Two hundred and thirty-four subjects with normal body weight and 101 obese subjects were allocated randomly to one(More)
Mivacurium ist das erste für die klinische Anwendung zugelassene kurzwirkende nicht depolarisierende Muskelrelaxans. Seine Benzylisochinolinstruktur wird durch die Plasmacholinesterase gespalten und die neuromuskulär blockierende Wirkung der Substanz beendet. Pharmakologie: Die klinische Wirkdauer einer Intubationsdosis von 0,2 mg/kg Mivacurium (2,5fache(More)