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Nootropic α7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators
- Herman J Ng, E. R. Whittemore, K. Gee
- Biology, PsychologyProceedings of the National Academy of Sciences
- 8 May 2007
A selective α7 nAChR-positive allosteric modulator (PAM) from a library of GABAA receptor PAMs is generated, which corrects sensory-gating deficits and improves working memory, effects consistent with cognitive enhancement in rodent models.