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OBJECTIVE To evaluate the efficacy and safety of perampanel 2, 4, and 8 mg/day added to 1-3 concomitant antiepileptic drugs (AEDs) in patients with uncontrolled partial-onset seizures. METHODS During this double-blind, placebo-controlled trial, patients with persisting seizures on 1-3 AEDs were randomized to perampanel 2, 4, and 8 mg/day or placebo(More)
This article presents an automated, patient-specific method for the detection of epileptic seizure onset from noninvasive electroencephalography. We adopt a patient-specific approach to exploit the consistency of an individual patient's seizure and nonseizure electroencephalograms. Our method uses a wavelet decomposition to construct a feature vector that(More)
An interactive automatic procedure for detection of malaria from microscope blood images is presented. The user is required to select image from data set and the algorithm detects whether the blood is infected with malaria or not automatically. This method will help in reducing the time taken for diagnosis and the chance for human errors. A general(More)
OBJECTIVES To determine whether pharmacodynamic interactions between high doses of lacosamide (400-800 mg/day) and concomitant sodium channel antiepilepsy drugs (AEDs) can be minimized in patients with drug-resistant partial-onset seizures. MATERIALS AND METHODS Patients were rapidly initiated with high-dose lacosamide (100 mg/week; increases to 400 to(More)
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