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Global Burden of Cancer
TLDR
The GLOBOCAN 2002 database was first made available in September 2005 and presented estimates for 2002, based on the most recent incidence, mortality, and survival data available at IARC, but more recent figures may be available directly from local sources. Expand
Randomized Controlled Trial of Aerobic Exercise on Insulin and Insulin-like Growth Factors in Breast Cancer Survivors: The Yale Exercise and Survivorship Study
Background: High insulin and insulin-like growth factor-I (IGF-I) levels may be associated with an increased breast cancer risk and/or death. Given the need to identify modifiable factors thatExpand
Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women.
TLDR
It is suggested that hyperinsulinemia is an independent risk factor for breast cancer and may have a substantial role in explaining the obesity-breast cancer relationship. Expand
Physicians’ Weight Loss Counseling in Two Public Hospital Primary Care Clinics
TLDR
Physicians’ weight loss counseling had a significant effect on patients’ understanding of and motivation for weight loss, however, physicians provided insufficient guidance on weight management strategies, possibly because of inadequate counseling skills and confidence. Expand
Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk.
TLDR
Although smoking is the dominant risk factor of lung cancer, XPA -4G>A (rs1800975) is also associated with the risk of NSCLC, especially for squamous cell carcinoma, among Asian young smokers and the NER pathway seems to have more strong influences on lung cancer than the BER pathway. Expand
Type I and II endometrial cancers: have they different risk factors?
TLDR
The results of this pooled analysis suggest that the two endometrial cancer types share many common etiologic factors, and the etiology of type II tumors may, therefore, not be completely estrogen independent, as previously believed. Expand
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer
TLDR
An association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 is identified, consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreaticcancer than those with groups A or B. Expand
Diagnostic Markers for Early Detection of Ovarian Cancer
TLDR
The first blood biomarker test with a sensitivity of 95.3% and a specificity of 99.4% for the detection of ovarian cancer is described, which has the potential for efficient screening in patients who are at high risk for ovarian cancer. Expand
High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-β1
TLDR
The study shows that high miR-21 expression was associated with features of aggressive disease, including high tumor grade, negative hormone receptor status, and ductal carcinoma, and supports the notion that mi R-21 is an onco-microRNA for breast cancer. Expand
Detectable clonal mosaicism and its relationship to aging and cancer
TLDR
Large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases. Expand
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