Herbert Wheeler

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BACKGROUND Bisphosphonates such as pamidronate disodium inhibit osteoclast-induced bone resorption associated with cancer that has metastasized to bone. METHODS Women with stage IV breast cancer who were receiving cytotoxic chemotherapy and had at least one lytic bone lesion were given either placebo or pamidronate (90 mg) as a two-hour intravenous(More)
PURPOSE Pamidronate, an aminobisphosphonate, has been shown to lower the risk of skeletal complications associated with lytic bone lesions for up to 1 year in women with stage IV breast cancer who received chemotherapy. We studied the long-term effectiveness and safety of continued treatment with intravenous pamidronate infusions for up to 2 years. (More)
OBJECTIVE To measure local (peritoneal fluid) and systemic (plasma) cytokine profiles in patients with infection-inflammation of the vermiform appendix, a relatively mild, localized inflammatory process. SUMMARY BACKGROUND DATA The systemic host response to invading microorganisms, often termed the systemic inflammatory response syndrome (SIRS), includes(More)
PURPOSE To evaluate the transjugular intrahepatic portosystemic shunt (TIPS) as primary treatment in patients with cirrhosis and severe ascites. MATERIALS AND METHODS A TIPS placement was attempted in 54 consecutive patients with intractable ascites. Clinical assessment findings, shunt patency, complications, and survival were analyzed. RESULTS A TIPS(More)
PURPOSE The authors report results of high-dose thrombolytic therapy in native arteries and vein grafts and discuss the various factors affecting outcome. PATIENTS AND METHODS In a retrospective study, the outcome of 82 high-dose urokinase infusions in 76 patients was examined. Comorbid risk factors as they relate to outcome were studied extensively with(More)
OBJECTIVE The purpose of this study was to retrospectively compare two-dimensional time-of-flight MR angiography with other imaging procedures in the evaluation of the portal venous system in 152 consecutive patients. MATERIALS AND METHODS The findings on MR angiography performed on 152 patients to depict breath-hold, two-dimensional time of flight MR(More)
OBJECTIVE To assess the combination of duplex Doppler ultrasound (DUS) and complete carotid magnetic resonance angiography (MRA) for the non-invasive imaging of carotid disease and their effect on outcomes. Determine inter-reader agreement of carotid MRA. MATERIALS AND METHODS One-hundred and ten carotid bifurcations were evaluated using DUS, 2D and 3D(More)
To assess the impact of noninvasive testing of the carotid vessels upon patient management, we analyzed the angiographic findings in 494 patients studied between 1978 and 1983 for suspected extracranial cerebrovascular disease. This longitudinal study revealed two changes in the pattern of angiographic results after introduction of noninvasive testing in(More)
Twenty patients with advanced squamous cell carcinomas (SCC) of the head and neck were entered into a phase II study of mitoxantrone at a dosage of either 12 mg/m2 or 14 mg/m2 given at 3 weekly intervals. None of the patients had received prior chemotherapy. One patient had a partial remission. Two patients died from unrelated causes. One patient withdrew(More)