Herbert Szeto

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We studied the effect of opioid blockade with naloxone on the EEG of rats maintained chronically with i.v. catheters and cortical electrodes. EEG was analyzed on line by fast fourier transform, and drug was given as bolus injections during nighttime, active periods. Naloxone caused increases in EEG amplitude, reflected as increased total spectral power, for(More)
We evaluated the usefulness of detection systems and diagnostic decision support systems for bioterrorism response. We performed a systematic review by searching relevant databases (e.g., MEDLINE) and Web sites for reports of detection systems and diagnostic decision support systems that could be used during bioterrorism responses. We reviewed over 24,000(More)
Rats with chronically implanted jugular catheters and cortical EEG electrodes were allowed 24 hr per day access to morphine infusions (30 micrograms/kg) contingent on lever-pressing. Yoked control subjects received the same number and pattern of infusions as contingent subjects in an adjacent cage. Six subjects were studied, with data analyzed over 84 days(More)
EEG measures that vary on a continuous scale, without separating behavior into discrete states, may complement sleep staging as a means of characterizing diurnal variation in level of arousal. The object of the present study was to evaluate diurnal variation in the EEG power spectrum averaged independently of sleep state, and to determine which parameters(More)
Heightened arousal occurring in response to physical or psychological stressors in associated with increased levels of endogenous opioid peptides in peripheral circulation and at binding sites in the central nervous system. When administered as a series of bolus injections during active periods, the opioid antagonist naloxone increased delta wave activity(More)
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