Herbert Silver

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A clinical trial of adoptive immunotherapy was carried out with peripheral blood lymphocytes (PBL), cocultured in vitro with autologous tumor cells and interieukin-2 (IL-2), in 14 patients with advanced melanoma. PBL from these patients were cocultured with irradiated autologous tumor cells for 7 days, which was followed by expansion in IL-2-containing(More)
Cooperation between thymus-derived (T) t and nonthymus-derived (B) cells occurs in primary and secondary humoral antibody responses of mice to heterologous erythro-cytes and serum proteins (1-3). Recent experiments have demonstrated that T as well as B cells can react to antigen specifically and therefore dictate the specificity of the response (1, 4).(More)
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