Herbert Meissner

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The effect of a "square wave" stimulation with glucose or glibenclamide on the electrical activity of beta-cells has been studied with microelectrode techniques in isolated perifused mouse islets. While glucose evoked a burst activity with periodic oscillations of the membrane potential between two levels, glibenclamide produced a constant depolarization(More)
The endothelial receptors that control leukocyte transmigration in the postischemic liver are not identified. We investigated the role of junctional adhesion molecule-A (JAM-A), a receptor expressed in endothelial tight junctions, leukocytes, and platelets, for leukocyte transmigration during hepatic ischemia-reperfusion (I/R) in vivo. We show that JAM-A is(More)
1. The electrical activity of beta-cells is characterized by a regular burst pattern. 2. The bursts occur in a potential range which is not dependent on external glucose concentration. However, there is a clear dose-response relationship between spike frequency or plateau duration and the glucose concentration. 3. There is a striking biphasic pattern of the(More)
The effects of forskolin, an activator of adenylate cyclase, on the membrane potential of pancreatic B cells have been studied with microelectrodes. Forskolin (5 microM) did not affect the stable resting membrane potential (3 mM glucose). In the presence of 10 mM glucose, forskolin lengthened the slow waves with superimposed spikes and shortened the(More)
The ionic basis of the glucose-induced membrane potential changes in pancreatic B-cells was investigated. The results suggest that the initial depolarization of the membrane in response to a stimulation with glucose is due to a decrease of the K permeability. This depolarization seems to open a voltage-dependent Ca-channel and thereby an additional(More)
Push-pull cannulae were implanted into the preoptic/anterior hypothalamic area (POA) of ovariectomized (OVX) rats. After recovery animals were treated with estradiol (E2) or corn oil and they were perfused 3 days later. Substance P (SP) concentrations were measured in 15 min perfusate fractions, blood samples were taken at similar intervals. SP(More)
The membrane potential of mouse pancreatic beta-cells was measured with microelectrodes. In the resting cell (3 mM D-glucose), the membrane potential was -63 +/- 3 mV (mean +/- S.E. for four experiments). In the presence of 3 mM D-glucose, total Cl- substitution by isethionate induced a depolarization by 3-4 mV, and readmission of Cl- induced a(More)
The general purpose of the magnetohydrodynamic research is to explore interaction phenomena in those situations in which the fluid can be considered to be predominantly a continuum. This includes a wide range of phenomena, from the flow of liquid metals through magnetic fields to the propagation of hydromagnetic shock waves. At the present time, we are(More)
On the semantical interpretation of linguistic entities that function structurally E. S. Klima, Structure at the lexical level and its implications for transfer grammar G. H. Matthews, Analysis by synthesis of sentences of natural languages