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While model-based process monitoring and system identiication share the common goal of describing the behavior of a physical system based on a mathematical model, the assumptions made by system identiication are typically too strong to apply it directly to monitoring problems. This article describes SQUID, a new system identiication method that uses(More)
Using a series of techniques to identify and deplete various peripheral blood lymphocyte subpopulations, we studied the cytotoxic reactivity of normal individuals against the myeloid cell line K-562 in a 4-hr 51chromium-release assay. Depletion of lymphocytes bearing complement receptors had a variable, usually negligible effect on cytotoxicity. In(More)
System identification takes a space of possible models and a stream of observational data of a physical system, and attempts to identify the element of the model space that best describes the observed system. In traditional approaches, the model space is specified by a parameterized differential equation, and identification selects numerical parameter(More)
Lymphocytes with Fc receptors (FcR) for IgG active in natural cytotoxicity and antibody-dependent cellular cytotoxicity were separated into sheep erythrocyte rosetting (E+) and nonrosetting (E-) fractions, and examined for reactivity with the OK panel of hybridoma-produced monoclonal antibodies. Few cells in either the E+ FcR+ or the E- FcR+ fraction(More)
Peripheral blood granulocytes from normal healthy donors were found to reproducibly inhibit the cytolytic effector function of specifically sensitized cytotoxic T lymphocytes in vitro when co-incubated with these effector cells and target cells in 8 hr 51Cr release assays. Inhibition required intact granulocytes, was proportional to the number of(More)