Herb Szeto

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EEG measures that vary on a continuous scale, without separating behavior into discrete states, may complement sleep staging as a means of characterizing diurnal variation in level of arousal. The object of the present study was to evaluate diurnal variation in the EEG power spectrum averaged independently of sleep state, and to determine which parameters(More)
Rats with chronically implanted jugular catheters and cortical EEG electrodes were allowed 24 hr per day access to morphine infusions (30 micrograms/kg) contingent on lever-pressing. Yoked control subjects received the same number and pattern of infusions as contingent subjects in an adjacent cage. Six subjects were studied, with data analyzed over 84 days(More)
The synthetic opioid peptide analog Tyr-D-Ala-Gly-N-methyl-Phe-Gly-ol (DAMGO), which is a mu opioid receptor-selective agonist, was quantified in ovine plasma samples with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS), using delayed extraction and a reflectron. The internal standard was pentadeuterated DAMGO.(More)
We studied the effect of opioid blockade with naloxone on the EEG of rats maintained chronically with i.v. catheters and cortical electrodes. EEG was analyzed on line by fast fourier transform, and drug was given as bolus injections during nighttime, active periods. Naloxone caused increases in EEG amplitude, reflected as increased total spectral power, for(More)
OBJECTIVE To evaluate and compare Mohs micrographic surgery and traditional excision in terms of cost and outcomes. DESIGN We developed a computer-simulation, probabilistic, decision model to perform a cost-effectiveness analysis, with each patient serving as his or her own control. SETTING University of Connecticut dermatology clinic, a tertiary care(More)
Heightened arousal occurring in response to physical or psychological stressors in associated with increased levels of endogenous opioid peptides in peripheral circulation and at binding sites in the central nervous system. When administered as a series of bolus injections during active periods, the opioid antagonist naloxone increased delta wave activity(More)
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