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Cytosine residues in the sequence 5'CpG (cytosine-guanine) are often postsynthetically methylated in animal genomes. CpG methylation is involved in long-term silencing of certain genes during mammalian development and in repression of viral genomes. The methyl-CpG-binding proteins MeCP1 and MeCP2 interact specifically with methylated DNA and mediate(More)
DNA-(cytosine-5) methyltransferase (MCMT) methylates newly replicated mammalian DNA, but the factors regulating this activity are unknown. Here, MCMT is shown to bind proliferating cell nuclear antigen (PCNA), an auxiliary factor for DNA replication and repair. Binding of PCNA requires amino acids 163 to 174 of MCMT, occurs in intact cells at foci of newly(More)
In addition to its well-documented effects on gene silencing, cytosine methylation is a prominent cause of mutations. In humans, the mutation rate from 5-methylcytosine (m5C) to thymine (T) is 10-50-fold higher than other transitions and the methylated sequence CpG is consequently under-represented. Over one-third of germline point mutations associated with(More)
293 PERSPECTIVES are caused by loss of some of the synMuv B chromatin regulators (5, 7, 8). Notably, although LIN-53 is a member of the synMuv B group, some experiments (8) suggest that it is not among the synMuv B proteins whose loss causes a strong soma-to-germ transformation. Figuring out which chromatin regulators limit competence to respond to(More)
Rasbora dusonensis, R. tornieri and R. myersi are valid species. Rasbora dusonensis sensu Brittan (1954) is R. tornieri and R. dusonensis sensu Kottelat (1991) is R. myersi. Both R. dusonensis and R. tornieri are members of the R. argyrotaenia group and can be distinguished from congeners in having a broad, dark, sharply-defined midlateral stripe on body(More)
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