Henry Schmitt

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Raloxifene, a selective estrogen receptor modulator approved for the prevention and treatment of postmenopausal osteoporosis, has shown a significant reduction in breast cancer incidence after 3 years in this placebo-controlled, randomized clinical trial in postmenopausal women with osteoporosis. This article includes results from an additional annual(More)
Raloxifene effectively reduces the incidence of vertebral fractures in patients with postmenopausal osteoporosis. Recent data suggest that low-dose monofluorophosphate (MFP) plus calcium reduces the vertebral fracture rate in postmenopausal women with moderate osteoporosis. The objective of this study was to evaluate the combination of raloxifene and MFP in(More)
OBJECTIVES To examine, in a post-hoc, integrated analysis, the first-dose success, cumulative success by dose, and maintenance of success among men taking tadalafil. Early treatment success is important to men with erectile dysfunction. METHODS In five double-blind, placebo-controlled, 12-week studies, men were randomized to placebo (n = 308), tadalafil(More)
INTRODUCTION Although depression is often associated with poor glycemic control in patients with type 2 diabetes mellitus (T2DM), this observation has been inconsistent. This exploratory, post hoc analysis investigated associations between depression parameters and glycemic control using data from a 24-month, prospective, observational, non-interventional(More)
INTRODUCTION Erectile dysfunction (ED) is a self-reported condition and satisfaction with sexual performance is individual, subjective, and multi-factorial. Treatment success depends on several outcomes. Tadalafil is a long-acting, selective inhibitor of phosphodiesterase 5 that has been shown to be effective at treating men with ED. AIM To investigate(More)
INTRODUCTION The DETECT study is a prospective, 12-month, European, multicenter, observational study of patients with erectile dysfunction (ED) initiating or changing treatment to tadalafil in routine clinical practice. AIM To determine the effectiveness of tadalafil and the factors associated with the continuation of treatment for ED at 12 months. (More)
INTRODUCTION The Erectile Dysfunction Observational Study (EDOS) is a 6-month, pan-European prospective, observational study of health outcomes designed to assess patients' profiles and characteristics and the effectiveness of erectile dysfunction (ED) treatment in routine clinical practice. AIM To present baseline characteristics and treatment-seeking(More)
OBJECTIVE To evaluate whether patterns of sexual activity and efficacy over time to two dosing regimens of tadalafil differ with ageing in men with erectile dysfunction (ED). PATIENTS AND METHODS The SURE study was a multicentre, crossover, open-label study. In all, 4262 men with ED were randomly assigned to treatment with tadalafil 20 mg on-demand before(More)
INTRODUCTION Erectile dysfunction (ED) is distressing and can affect a couple's relationship. AIM To investigate partner awareness of ED, relationship problems, and the effects of tadalafil treatment over 12 months. METHODS The Determinants of Continued Use of Tadalafil study is a prospective 12-month European observational study in patients with ED(More)
Robert J. Heine Eli Lilly and Company, Indianapolis, IN, USA Open Access. This article is distributed under the terms of the Creative Commons AttributionNonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4. 0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate(More)