Henry K. Cheah

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Fresh osteochondral allografts were used to repair articular defects in the distal femur in 72 patients. Sixty patients were available for long-term followup (mean, 10 years) to determine graft survivorship and patient outcomes using a modified Hospital for Special Surgery score. Twelve of 60 grafts have failed with three having graft removal alone and nine(More)
Analysis of the Ig switch (S) region structure from many stable isotype-switched B cells reveals that the majority of the ultimate switch recombination sites are located at the 5' end, or even upstream of the 5' end of the Smu region. These findings strongly contrast with results from switch circle analysis which reveal that the primary switch recombination(More)
Fresh osteochondral allografts are used to repair osteoarticular defects of the knee. For post-traumatic defects recent advances in other techniques for cartilage repair and resurfacing have reduced the role of allograft tissue transplantation to defects larger than 3 cm in diameter and 1 cm in depth. A fresh osteochondral allograft that has been harvested(More)
In RNA from human IgE-producing lymphocytes, we previously discovered two alternatively spliced epsilon-immunoglobulin mRNA isoforms that encode a novel secreted form of IgE and a membrane-bound species. Further analysis using epsilon-specific reverse transcriptase polymerase chain reactions has elucidated several additional alternatively spliced species of(More)
Fresh osteochondral allografts were used for post-traumatic knee defects >3 cm in diameter and 1 cm in depth. Harvesting of the grafts was carried out within 24 hours of the death of the donor, and implantation into the recipient was carried out within 72 hours. The grafts were unipolar, fixed by screws, and combined with realignment osteotomy if a(More)
We have developed an in vitro recombination system employing cell-free nuclear extracts from human B lymphocytes capable of detecting the recombination between human mu switch (Smu) and Sepsilon sequences in a model plasmid. Nuclear extracts from CD40-stimulated B lymphocytes gave a higher frequency of recombination in the assay than the unstimulated B(More)
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