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Web caching and prefetching are well known strategies for improving the performance of Internet systems. When combined with web log mining, these strategies can decide to cache and prefetch web documents with higher accuracy. In this paper, we present an application of web log mining to obtain web-document access patterns and use these patterns to extend(More)
—Caching is a well-known strategy for improving the performance of Web-based systems. The heart of a caching system is its page replacement policy, which selects the pages to be replaced in a cache when a request arrives. In this paper, we present a Web-log mining method for caching Web objects and use this algorithm to enhance the performance of Web(More)
Caching is one of the most eeective techniques for improving the performance of Internet systems. The heart of a caching system is its page replacement policy, which decides which page to replace in a cache by a new one. Diierent caching policies have dramatically diierent eeects on the system performance. In this paper, we extend the well-known GDSF(More)
The acute and chronic effects of tumour necrosis factor-alpha (TNF-alpha) on leptin production by human preadipocytes, differentiated preadipocytes, and mature adipocytes have been examined by competitive RT-PCR of leptin mRNA and by western blotting. In preadipocytes, secreted leptin was detectable after 5-day incubation in differentiation medium and this(More)
Adipocytes contain large lipid droplets in their cytoplasm. When cultured, they float on top of the medium, clump together, and do not gain equal and sufficient access to the medium. Morphological changes cannot be observed and the majority of adipocytes undergo cell lysis within 72 h of isolation. We have used a ceiling culture method for human mature(More)
Web caching and prefetching have been studied in the past separately. In this paper, we present an integrated architecture for Web object caching and prefetching. Our goal is to design a prefetching system that can work with an existing Web caching system in a seamless manner. In this integrated architecture, a certain amount of caching space is reserved(More)
Tumor necrosis factor-alpha (TNF alpha) can decrease adipose tissue mass, but in obesity, adipose tissue hypertrophy persists despite increased TNF alpha expression. The hormonal milieu of obesity may antagonize the adipostat effects of TNF alpha. We examined the effects of insulin and the synthetic glucocorticoid, dexamethasone (Dex), on TNF alpha-induced(More)
Leptin, the ob gene product of adipocytes, regulates body weight by actions on the satiety center in the hypothalamus, but it may also have peripheral effects on the metabolic actions of insulin. In human mature adipocytes isolated from omental (OM) and s.c. tissue, we found that leptin (10 and 100 ng/mL) significantly reduced insulin-mediated glucose(More)
Caching and prefetching are well known strategies for improving the performance of Internet systems. The heart of a caching system is its page replacement policy, which selects the pages to be replaced in a proxy cache when a request arrives. By the same token, the essence of a prefetching algorithm lies in its ability to accurately predict future request.(More)
Case-based reasoning aims to use past experience to solve new problems. A strong requirement for its application is that extensive experience base exists that provides statistically significant justification for new applications. Such extensive experience base has been rare, limiting most CBR applications to be confined to small-scale problems involving(More)
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