Henry Giera

  • Citations Per Year
Learn More
Cyclophosphamide and some of its major metabolites were dialyzed against bovine-serum-albumin and human-blood-serum until equilibrium. From Scatchard plots the strength and stoechiometry of protein-binding were determined. Cyclophosphamide, carboxyphosphamide and 4-ketocyclophosphamide were found to be bound only weakly and without specific binding sites.(More)
Lead finding strategies in pharmaceutical research comprise structure-based drug design as well as screening efforts of natural product pools or large chemical libraries. In this context we propose a combined approach by utilizing natural product-derived structure information on receptor- or enzyme-complementary for designing unique core structures that can(More)
  • 1