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OBJECTIVES This study sought to determine the feasibility of performing a comprehensive cardiac computed tomographic (CT) examination incorporating stress and rest myocardial perfusion imaging together with coronary computed tomography angiography (CTA). BACKGROUND Although cardiac CT can identify coronary stenosis, very little data exist on the ability(More)
Limited data are available concerning the effects of mild-to-moderate, sustained reductions of coronary blood flow on myocardial aerobic metabolism. This study tested the hypothesis that a sustained flow reduction distal to a severe coronary artery stenosis may be well tolerated (after the initial insult is passed) because of gradual improvement in the(More)
BACKGROUND We tested the hypothesis that correction of hyperlipidemia improves coronary vasodilator response and maximal perfusion in myocardial regions having substantial impairment of pretreatment vasodilator capacity. METHODS AND RESULTS Measurements of myocardial blood flow were made with PET [13N]ammonia in 12 patients with ischemic heart disease (11(More)
To determine whether a reduction in myocardial oxygen demand or an increase in coronary blood flow or both are responsible for the salutory effect of intraaortic balloon counterpulsation (IABP) in relieving medically refractory angina, we assessed these variables in six patients in whom IABP was required for relief of myocardial ischemia. IABP decreased the(More)
Alexithymia is conceptualized as both affect-deficit disorder and continuous personality variable. Two-hundred-sixty-four adolescents were surveyed using (1) a core symptom questionnaire for alexithymic state; (2) the Toronto Alexithymia Scale (TAS), and (3) the Solacing Methods Questionnaire. Three percent were positive for core symptoms and used(More)
This study tested the hypothesis that intrinsic negative inotropic effects of a drug used to induce coronary vasodilation distal to a severe coronary arterial stenosis may influence the extent of redistribution of transmural flow and its metabolic consequences. To test this hypothesis, studies were conducted in eight closed-chest, sedated swine with severe(More)
SUMMARY Stimulation of coronary artery a receptors may decrease regional myocardial blood flow in patients with coronary artery disease. We studied 13 closed-chest conscious pigs to compare the role of vaso-constriction of coronary conductance vessels and that of arteriolar resistance vessels in this response. An artificial stenosis 7.5 mm long that caused(More)
This study tested the hypothesis that myocardial tissue acidosis is responsible for maintenance of reduced arteriolar tone distal to a severe coronary arterial stenosis. Domestic swine (n = 10) were instrumented with a coronary arterial stenosis that reduced vessel diameter 80%. Measurements of hemodynamic indexes were made 1) before stenosis, 2) at 5, 20,(More)
BACKGROUND This study tested the hypotheses in the setting of a coronary artery stenosis that 1) planar 99mTc-teboroxime myocardial scans are capable of providing a good estimate of relative coronary flow reserve, and 2) delayed washout of the tracer from the myocardium is a marker of reduced myocardial blood flow and, in certain cases, myocardial ischemia.(More)