Henry Gewirtz

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OBJECTIVES This study sought to determine the feasibility of performing a comprehensive cardiac computed tomographic (CT) examination incorporating stress and rest myocardial perfusion imaging together with coronary computed tomography angiography (CTA). BACKGROUND Although cardiac CT can identify coronary stenosis, very little data exist on the ability(More)
BACKGROUND We tested the hypothesis that correction of hyperlipidemia improves coronary vasodilator response and maximal perfusion in myocardial regions having substantial impairment of pretreatment vasodilator capacity. METHODS AND RESULTS Measurements of myocardial blood flow were made with PET [13N]ammonia in 12 patients with ischemic heart disease (11(More)
Limited data are available concerning the effects of mild-to-moderate, sustained reductions of coronary blood flow on myocardial aerobic metabolism. This study tested the hypothesis that a sustained flow reduction distal to a severe coronary artery stenosis may be well tolerated (after the initial insult is passed) because of gradual improvement in the(More)
Alexithymia is conceptualized as both affect-deficit disorder and continuous personality variable. Two-hundred-sixty-four adolescents were surveyed using (1) a core symptom questionnaire for alexithymic state; (2) the Toronto Alexithymia Scale (TAS), and (3) the Solacing Methods Questionnaire. Three percent were positive for core symptoms and used(More)
Characterization of subacute and convalescent fibrotic burden in the remote myocardium after acute infarction provides strong and incremental prediction of changes in left and right functions and final infarct size, incremental to knowledge of the subacute infarct size Summary To test the hypothesis that fibrotic burden in remote myocardium quantified by(More)
SUMMARY. The purpose of this study was to test the hypothesis that adenosine is required to maintain arteriolar vasodilation distal to a severe coronary stenosis. Eight closed-chest conscious pigs were prepared by placing a 7.5-mm long stenosis (82% lumenal diameter reduction) in the proximal left anterior descending coronary artery. Regional myocardial(More)
This study tested the hypothesis that intrinsic negative inotropic effects of a drug used to induce coronary vasodilation distal to a severe coronary arterial stenosis may influence the extent of redistribution of transmural flow and its metabolic consequences. To test this hypothesis, studies were conducted in eight closed-chest, sedated swine with severe(More)
SUMMARY Stimulation of coronary artery a receptors may decrease regional myocardial blood flow in patients with coronary artery disease. We studied 13 closed-chest conscious pigs to compare the role of vaso-constriction of coronary conductance vessels and that of arteriolar resistance vessels in this response. An artificial stenosis 7.5 mm long that caused(More)
  • Michael K Cheezum, Prem Srinivas Subramaniyam, +14 authors Ron Blankstein
  • 2015
AIMS We sought to compare the complementary prognostic value of exercise treadmill testing (ETT) and coronary computed tomographic angiography (CTA) among patients referred for both exams. METHODS AND RESULTS We studied 582 patients without known coronary artery disease (CAD) who were clinically referred for ETT and CTA within 6 months. Patients were(More)