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As early as 1930 the first adverse health effects of vinyl chloride (VC) were reported.' Since then, numerous observations and studies have indicated a wide range of toxicity attributable to the effects of VC on the central nervous system, the liver, the bones of the fingers, and the Lately, the spectrum of known toxic effects of VC broadened to include(More)
Lead poisoning is an important environmental disease that can have life-long adverse health effects. Most susceptible are children, and most commonly exposed are those who are poor and live in developing countries. Studies of children's blood-lead levels (BLLs) are showing cognitive impairment at increasingly lower BLLs. Lead is dangerous at all levels in(More)
The Drake Superfund site in Clinton County, Pennsylvania, has been contaminated with the carcinogens beta-naphthylamine, benzidene, and benzene. The authors reviewed county-wide, age-adjusted, sex-, race-, and site-specific cancer mortality rates for the years 1950-1959, 1960-1969, and 1970-1979, and type-specific birth defects incidence rates for(More)
Extrapolations from animal toxicity experiments (including carcinogenicity and reproductive effects) to possible human heath effects can be used to estimate a reasonable level of risk for 2,3,7,8-tetrachlorodibenzodioxin (2,3,7,8-TCDD). Extrapolations are derived from: (1) review of published studies, (2) a complex set of assumptions related to human(More)
A reference range data base containing serum chemistry and hematology values on over 3000 animals is described. Data listed include the mean, standard deviation, and 10th and 90th percentiles for each of the following parameters. Serum chemistry: sodium, potassium, chloride, calcium, inorganic phosphorus, urea nitrogen, creatinine, total bilirubin, total(More)
Chemistry tests were conducted on serum from young Beagle dogs in order to deter mine the effect of age on these parameters. Blood was collected at regular intervals from 25 normal Beagle puppies (13 males and 12 females) at ages ranging from 2 weeks to 12 months. Serum chemistry profiles, protein electrophoresis and radioimmunoassays for thyroxine and(More)
The twentieth century has witnessed the appearance of a whole new series of man-made or technological disasters, resulting from enormously increased industrial growth and chemical utilization. Vast amounts of chemical or potential energy are now focused in highly concentrated areas; unanticipated events can lead to uncontrollable releases with devastating(More)
OBJECTIVES To study the incidence of eosinophilia-myalgia syndrome, the risk factors associated with the syndrome, and the clinical spectrum of illness associated with L-tryptophan use in an exposed population. DESIGN Retrospective cohort and nested case-control studies of risk factors for eosinophilia-myalgia syndrome using inpatient and outpatient chart(More)
Studies have shown blood lead levels of some children in South Africa at levels of health concern. New studies show even relatively low lead levels to have detrimental effects on cognitive function in young children. Large numbers of South African inner-city and other children have been shown to have unacceptably high blood lead levels. Studies indicate(More)