Henry F. McFarland

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W. Ian McDonald, Alastair D Compston, +13 authors Jerry S. Wolinsky
Annals of neurology
2001

The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and… (More)

Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria".

Chris H. Polman, Stephen C. Reingold, +11 authors Jerry S. Wolinsky
Annals of neurology
2005

New diagnostic criteria for multiple sclerosis integrating magnetic resonance image assessment with clinical and other paraclinical methods were introduced in 2001. The "McDonald Criteria" have been… (More)

Multiple sclerosis: a complicated picture of autoimmunity

Henry F. McFarland, Roland Martin
Nature Immunology
2007

Understanding of autoimmune diseases, including multiple sclerosis, has expanded considerably in recent years. New insights have been provided by not only animal models but also studies of patients,… (More)

Immunological aspects of demyelinating diseases.

Roland Martin, Henry F. McFarland, Dale E. McFarlin
Annual review of immunology
1992

Primary demyelination in the central nervous system results from damage to the myelin sheath or oligodendroglia and can be produced by a variety of mechanisms, including metabolic disturbances,… (More)

Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients

Paolo Antonio Muraro, Daniel C. Douek, +11 authors Roland Martin
The Journal of experimental medicine
2005

Clinical trials have indicated that autologous hematopoietic stem cell transplantation (HSCT) can persistently suppress inflammatory disease activity in a subset of patients with severe multiple… (More)

Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell…

Paolo Antonio Muraro, Marco Vergelli, +7 authors Roland Martin
The Journal of clinical investigation
1997

The pathogenesis of multiple sclerosis (MS) is currently ascribed in part to a T cell-mediated process targeting myelin components. The T cell response to one candidate autoantigen, myelin basic… (More)

Association of human herpes virus 6 (HHV-6) with multiple sclerosis: Increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA

Samantha S. Soldan, Rossana Berti, +9 authors Steven Jacobson
Nature Medicine
1997

Viruses have long been suggested to be involved in the etiology of multiple sclerosis (MS)1. This suggestion is based on (1) epidemiological evidence of childhood exposure to infectious agents and… (More)

Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon beta.

Bibiana Bielekova, Nancy D. Richert, +9 authors Roland Martin
Proceedings of the National Academy of Sciences…
2004

Identifying effective treatment combinations for MS patients failing standard therapy is an important goal. We report the results of a phase II open label baseline-to-treatment trial of a humanized… (More)

Identification of High Potency Microbial and Self Ligands for a Human Autoreactive Class II–restricted T Cell Clone

Bernhard Hemmer, Burkhard T. Fleckenstein, +4 authors K. -H. Wiesmüller
The Journal of experimental medicine
1997

CD4+ class II-restricted T cells specific for self antigens are thought to be involved in the pathogenesis of most human autoimmune diseases and molecular mimicry between foreign and self ligands has… (More)

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand

Bibiana Bielekova, Bonnie Goodwin, +9 authors Roland Martin
Nature Medicine
2000

Myelin-specific T lymphocytes are considered essential in the pathogenesis of multiple sclerosis. The myelin basic protein peptide (a.a. 83–99) represents one candidate antigen; therefore, it was… (More)

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