Henry F. Sears

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The binding of monoclonal antibody specific for colon carcinoma was inhibited by serum from patients with adenocarcinoma of the colon but not by serum from patients with other bowel diseases or from healthy volunteers. Of other malignancies studied, serum from two patients with gastric carcinoma and two patients with pancreatic carcinoma also inhibited the(More)
A phase-I clinical trial of a murine monoclonal antibody that specifically suppresses growth of human gastrointestinal tumours in athymic mice was conducted in four patients, who were given 15-200 mg purified antibody. The monoclonal antibody persisted in the circulation for more than a week when more than 15 mg was given. Antibodies against mouse(More)
The human c-myc proto-oncogene is the genomic homologue of the transforming sequences found in MC29, an avian retrovirus that can cause myelocytomatosis, carcinoma, sarcoma and lymphoma (Graf & Beug, 1978; Enrietto et al., 1983). Alterations in the structure or expression of c-myc have been associated with several forms of neoplasia including avian leukosis(More)
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A monosialoganglioside antigen of gastrointestinal adeno-carcinomas defined by murine monoclonal antibody was dem onstrated by immunoperoxidase (IP) assay in fixed paraffin-embedded tumors in 59% of colonie adenocarcinomas, 86% of pancreatic adenocarcinomas, and 89% of all gastric ade nocarcinomas. In all patients with detectable levels of antigen in(More)
A murine monoclonal antibody (MAb) which binds to human metastatic gastrointestinal adenocarcinomas can be administered safely and has tumor effects in some patients. Its therapeutic effect was assessed in 20 patients with measurable advanced colorectal carcinoma that was refractory to prior surgical resection, chemotherapy, and/or radiotherapy. All(More)
Of 66 specimens from benign melanocytic nevi, including common acquired and congenital nevi, Spitz tumors (epithelioid cell nevi), and melanocytic nevi with dysplasia, 57 could be grown in tissue culture. The cultured cells were identified as melanocytes by the presence of premelanosomes and melanosomes. Cells from 28 of 32 nevus cultures grew in an(More)
5 ABSTRACT.—Little is known about the post-fledging period in most bird species, and almost nothing has been reported for the family Emberizidae, including New World sparrows. We report here, for the first time, the sizes (wing length and body weight) of, and the distances traveled by fledgling Grasshopper Sparrows within their hatch summer in a restored(More)
A monoclonal antibody to a cell surface glycoprotein on human colorectal carcinomas was raised using the undifferentiated colon carcinoma cell line MIP 101 as the immunogen. This antibody, ND4, is an IgG2a which does not cross-react with carcinoembryonic antigen (CEA), non-specific cross-reacting antigen, or blood group substances A, B, and H.(More)
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