Henry Chan

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Telomerase adds telomeric repeats to chromosome ends using an internal RNA template and a specialized telomerase reverse transcriptase (TERT), thereby maintaining genome integrity. Little is known about the physical relationships among protein and RNA subunits within a biologically functional holoenzyme. Here we describe the architecture of Tetrahymena(More)
Partial body weight-supported treadmill training is an approach for gait rehabilitation. Variables such as stepping frequency and the amount of body weight support are key parameters manipulated during training. The purpose of this study was to quantify the extent to which body weight support and stride frequency contribute and interact to produce the(More)
Telomerase helps maintain telomeres by processive synthesis of telomere repeat DNA at their 3'-ends, using an integral telomerase RNA (TER) and telomerase reverse transcriptase (TERT). We report the cryo-electron microscopy structure of Tetrahymena telomerase at ~9 angstrom resolution. In addition to seven known holoenzyme proteins, we identify two(More)
INTRODUCTION Despite evidence that breast cancer screening reduces morbidity and mortality, many women do not obtain mammograms. Our objective was to analyze the relationship between income and mammography screening for members enrolled in a large health plan in Hawaii. METHODS We analyzed claims data for women (N = 46,328) aged 50 to 70 years during 2003(More)
In the middle of the last decade China began to develop the use of the Internet. Within a few years, the World Wide Web (WWW) had experienced rapid growth in terms of network infrastructure, shopping behaviour and numbers of Internet users. China currently maintains annual economic growth higher than anywhere else in the world. Consequently an increasing(More)
Organizing inorganic nanocrystals into complex architectures is challenging and typically relies on preexisting templates, such as properly folded DNA or polypeptide chains. We found that under carefully controlled conditions, cubic nanocrystals of magnetite self-assemble into arrays of helical superstructures in a template-free manner with >99% yield.(More)
Wolters Kluwer Law & Business is a leading provider of premier research products and tools in many legal practice areas, including a comprehensive suite of products designed to provide the most up-to-date and current information in franchise and distribution law. The CCH Business Franchise Guide, commonly referred to as the " bible of franchise law, " is(More)
Telomerase adds telomeric repeats to chromosome ends using an internal RNA template and specialized telomerase reverse transcriptase (TERT), thereby maintaining genome integrity. Little is known about the physical relationships among protein and RNA subunits within a biologically functional holoenzyme. Here we describe the architecture of Tetrahymena(More)