Henry Alexander Leder

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PURPOSE To compare the relative effectiveness and side effect profiles of antimetabolite drugs in the treatment of noninfectious ocular inflammation. DESIGN Retrospective cohort study. PARTICIPANTS A total of 257 patients with inflammatory eye disease seen in a single-center, academic practice and treated with an antimetabolite as a first-line(More)
PURPOSE To determine whether the use of ultra wide-field imaging changes the management or determination of disease activity in patients with noninfectious posterior uveitis. DESIGN Prospective, observational case series. METHODS setting: Divisions of Retina and Ocular Immunology at single academic medical center. patient population: Total of 43(More)
BACKGROUND The purpose of this study is to evaluate the ocular tolerability and efficacy of sirolimus administered as subconjunctival or intravitreal injections in patients with non-infectious uveitis. Sirolimus as a Therapeutic Approach for Uveitis (SAVE) is a prospective, randomized, open-label, interventional study. Thirty patients were enrolled and(More)
BACKGROUND The purpose of this study is to describe and quantify the benefit of ultra-wide-field imaging and fluorescein angiography (FA) in the management of non-infectious retinal vasculitis. In this prospective observational cohort series, patients with non-infectious retinal vasculitis were evaluated and enrolled by four investigators from the Divisions(More)
OBJECTIVE To evaluate the ocular reactivity of the rabbit to an intracameral injection of a dispersive ophthalmic viscosurgical device (OVD) containing various levels of bacterial endotoxin using slit-lamp biomicroscopy and laser flare photometry. DESIGN Experimental, randomized, masked animal study. PARTICIPANTS Thirty Dutch-Belted rabbits. METHODS(More)
PURPOSE To describe the effectiveness of periocular corticosteroid injections in the treatment of cystoid macular edema (CME) complicating noninfectious uveitis. DESIGN Retrospective cohort study. METHODS A total of 126 patients (156 eyes) were evaluated for presence of CME, visual acuity, intraocular pressure, degree of intraocular inflammation, and(More)
PURPOSE To report a case of visually significant band keratopathy associated with ocular inflammation and systemic hypercalcemia which markedly decreased in severity after treatment of these underlying factors. METHODS Retrospective case report. RESULTS A 53-year-old Asian female with granulomatous panuveitis in the left eye presented with diffuse band(More)
BACKGROUND While the development of targeted molecular therapy to inhibit vascular endothelial growth factor (VEGF) has revolutionized the treatment and visual prognosis of highly prevalent retinal diseases such as diabetic retinopathy and age-related macular degeneration, each intravitreal injection of these agents carries a small risk of endophthalmitis(More)
OBJECTIVE To investigate whether enzymatic detergents used in cleaning ophthalmic surgical instruments can cause toxic anterior segment syndrome (TASS)-like responses in a rabbit model. DESIGN Randomized, investigator-masked, controlled experimental animal study. PARTICIPANTS Thirty-five New Zealand white rabbits. METHODS The rabbit eyes were(More)