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A continuing challenge for preclinical research on anxiolytic drugs is to capture the affective dimension that characterizes anxiety and aggression, either in their adaptive forms or when they become of clinical concern. Experimental protocols for the preclinical study of anxiolytic drugs typically involve the suppression of conditioned or unconditioned(More)
The objective of the current research was to study the large individual differences in alcohol effects on aggressive behavior under systematically varied conditions in experimental protocols with mice. Three experiments were conducted with outbred Swiss-Webster derived mice that identified those individuals whose aggressive behavior was reliably heightened(More)
In order to investigate the influence of the route of administration on behavioural effects induced by apomorphine (APO), 6 increasing doses were administered by intraperitoneal and by subcutaneous route to male Wistar rats. Dose-response curves for stereotypy, rearing, sedation, grooming, yawning and penile erection were calculated. The occurrence of(More)
While anxiety appears to characterize humans who administer high doses of cocaine or experience withdrawal from cocaine, it is difficult to capture this aspect of cocaine effects in animals. The present study investigated if acute or protracted withdrawal from prolonged low-dose cocaine that is self-administered via the oral route could be detected in(More)
Although acute cocaine is a strong reuptake inhibitor at dopamine (DA), norepinephrine (NE) and serotonin (5-HT) synapses, the effects of chronic cocaine on 5-HT and NE transporters have received less attention than its effects on DA transporters. In the present study, quantitative autoradiography was used to map effects of chronic cocaine exposure on the(More)
Agonists acting at benzodiazepine, gamma-aminobutyric acidA, barbiturate and neurosteroid recognition sites were studied for their attenuation of separation-induced ultrasonic vocalizations (USV) in rat pups. The behavioral effects of the neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone) were assessed when the drug was administered(More)
Carbamazepine has been shown to enhance dopaminergic agonist behavioral effects, but not to displace [3H]spiroperidol binding. To verify if carbamazepine acts presynaptically on dopaminergic neurons, reuptake and release of [3H]dopamine were measured in rat striatal slices in vitro. It was observed that carbamazepine blocked 20% of the reuptake of(More)
Some clinical reports on antimanic, antidepressant and prophylactic effects of carbamazepine (CBZ) in manic-depressive illness have appeared since its initial use as an anticonvulsant drug. The present report deals with the effects of CBZ on two animal models of depression, namely the potentiation of amphetamine-induced anorexia, and the behavioral despair(More)
The use of estrogen and dopamine receptor antagonists is associated with elevated prolactin levels and, in rats, chronic estrogen treatment is also associated with lactotroph proliferation. In this study, haloperidol, fluphenazine, sulpiride and metoclopramide, alone or combined with estradiol, were administered to Wistar rats. Pituitary weight, serum(More)
Three experiments were performed in order to find if carbamazepine interacts with dopaminergic systems. In the first experiment carbamazepine itself did not induce stereotypy but it potentiated the apomorphine-elicited stereotypy. The potentiation was no longer seen in the second experiment with carbamazepine given chronically. Moreover, stereotyped(More)