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The emerging concept of systems medicine (or 'P4 medicine'-predictive, preventive, personalized and participatory) is at the vanguard of the post-genomic movement towards 'precision medicine'. It is the medical application of systems biology, the biological study of wholes. Of particular interest, P4 systems medicine is currently promised as a revolutionary(More)
A retrospective study was carried out among children admitted to the Pediatric Clinic, Haukeland Hospital, from 1958 until 1986 for accidental poisoning. Drugs was the most frequent poisoning agent (49%), followed by household agents (22%), different agents (20%) and plants/mushrooms (9%). 89% of the children were under five years of age, 57% were boys. 20%(More)
RATIONALE, AIMS AND OBJECTIVES The practicing doctor, and most obviously the primary care clinician who encounters the full complexity of patients, faces several fundamental but intrinsically related theoretical and practical challenges - strongly actualized by so-called medically unexplained symptoms (MUS) and multi-morbidity. Systems medicine, which is(More)
In a recent paper in PNAS by Naviaux et al. (1) on metabolomics in chronic fatigue syndrome (CFS), the authors claim to have discovered an objective, diagnostically useful “chemical signature” of the condition, and that this signature corresponds to a “hypometabolic response to environmental stress similar to dauer.” Although we salute the authors’(More)
Three infants developed severe hemolytic anemia following the second or third diphtheria-pertussistetanus vaccination. Direct antiglobulin tests were positive, and the infant most severely affected also had reduced serum complement levels, indicating an immunological mechanism for the hemolysis. The presence of IgM on the erythrocytes from 2 of the infants(More)
The scoring systems of Dubowitz et al. and Parkin et al. were evaluated in two selected materials of newborn infants referred to a neonatal unit. Our estimation of gestational age by Dubowitz scores tended to be too high for the extreme prematures. "Small-for-dates" were also overestimated, whilst "appropriate-for-dates" and infants with respiratory(More)
A computerized file of chemical information, "CHEMFO", was developed at BASF Wyandotte Corporation to help comply with the initial reporting requirements of the Toxic Substances Control Act. This organization and approach allowed collecting the required information on all the manufactured and imported chemicals, editing and entry of the data, structuring of(More)
Systems medicine, which is based on computational modelling of biological systems, is emerging as an increasingly prominent part of the personalized medicine movement. It is often promoted as 'P4 medicine' (predictive, preventive, personalized, and participatory). In this article, we test promises made by some of its proponents that systems medicine will be(More)