• Publications
  • Influence
Mitochondrial genome variation and the origin of modern humans
The analysis of mitochondrial DNA (mtDNA) has been a potent tool in our understanding of human evolution, owing to characteristics such as high copy number, apparent lack of recombination, highExpand
  • 1,316
  • 107
  • PDF
The evolution of gene expression levels in mammalian organs
Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented byExpand
  • 911
  • 90
  • PDF
Ancient Protostome Origin of Chemosensory Ionotropic Glutamate Receptors and the Evolution of Insect Taste and Olfaction
Ionotropic glutamate receptors (iGluRs) are a highly conserved family of ligand-gated ion channels present in animals, plants, and bacteria, which are best characterized for their roles in synapticExpand
  • 469
  • 81
  • PDF
Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genomeExpand
  • 2,382
  • 60
  • PDF
Origins, evolution, and phenotypic impact of new genes.
Ever since the pre-molecular era, the birth of new genes with novel functions has been considered to be a major contributor to adaptive evolutionary innovation. Here, I review the origin andExpand
  • 530
  • 55
  • PDF
Evolutionary fate of retroposed gene copies in the human genome.
Given that retroposed copies of genes are presumed to lack the regulatory elements required for their expression, retroposition has long been considered a mechanism without functional relevance.Expand
  • 323
  • 47
  • PDF
The evolution of lncRNA repertoires and expression patterns in tetrapods
TLDR
We present a large-scale evolutionary study of lncRNA repertoires and expression patterns, in 11 tetrapod species. Expand
  • 680
  • 45
Emergence of Young Human Genes after a Burst of Retroposition in Primates
The origin of new genes through gene duplication is fundamental to the evolution of lineage- or species-specific phenotypic traits. In this report, we estimate the number of functional retrogenes onExpand
  • 285
  • 30
  • PDF
Origins and functional evolution of Y chromosomes across mammals
Y chromosomes underlie sex determination in mammals, but their repeat-rich nature has hampered sequencing and associated evolutionary studies. Here we trace Y evolution across 15 representativeExpand
  • 322
  • 29
  • PDF
Birth and expression evolution of mammalian microRNA genes.
MicroRNAs (miRNAs) are major post-transcriptional regulators of gene expression, yet their origins and functional evolution in mammals remain little understood due to the lack of appropriateExpand
  • 238
  • 22
  • PDF