Henny Rigter

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Sexual receptivity of spayed female rats was studied by recording lordosis responses to a mounting male. Administration of apomorphine (0.25 mg/kg) to oestrogen+progesterone-primed females produced an increase in lordosis behaviour 2--48 hr after injection. An increase was also found when apomorphine was substituted for progesterone. These results suggest a(More)
These experiments investigated the effect of immediate posttrial administration of peripherally acting DL-4-hydroxyamphetamine on retention of a one-trial inhibitory avoidance response in intact, adrenal medullectomized, sympathectomized, and medullectomized and sympathectomized rats. In intact rats, 0.82 mg/kg of DL-4-OH-amphetamine enhanced retention(More)
Leu[Enkephalin (400.0 micrograms/kg) and the enkephalin analog [DAla,DLeu]enkephalin (0.4, 4.0, and 40.0 micrograms/kg) were intraperitoneally administered to rats 5 min before they were trained on aversively motivated tasks. The peptides impaired acquisition of a one-way active avoidance response, facilitated acquisition of an inhibitory avoidance(More)
Young (3-6 month) and old (24-27 month) barrier reared Wistar rats were tested for their ability to retain an inhibitory (passive) avoidance, acquired immobility, and a conditioned taste aversion response as a function of time. Old rats exhibited accelerated forgetting of both the inhibitory avoidance and acquired immobility response in comparison to young(More)
After bilateral olfactory bulbectomy in rats a significant increase of norepinephrine (NE) level in the hypothalamus was found. However, no difference was observed between hypothalamic NE turnover of bulbectomized and sham operated animals in the amygdaloid cortex the NE level was not affected by bulbectomy. In this area, however, the NE turnover appeared(More)
Peripheral i.p. administration of 1.0 microgram/kg gamma-endorphin to rats, 30 min prior to training in a 1-trial inhibitory avoidance task, enhanced retention performance measured 72 h later. A much smaller dose of 0.1 microgram/kg beta-endorphin administered immediately following training produced a retention deficit. Both of these endorphin effects were(More)
The ACTH 4-9 analog, H-Met((O2)-Glu-His-Ph-D-Lys-Phe-OH (Or 2766), attenuates in rats CO2-induced amnesia for a one-trial passive avoidance step-through response when administered prior to the retrieval test but not when given prior to acquisition. Even a dose of 0.001 mug/rat Org 2766 yields an anti-amnesic effect. In this respect Org 2766 is more active(More)
Abstract MBDB (N -methyl-1-(1,3-benzodioxol-5-yl)-2-aminobutane) is the alpha-ethyl homologue of MDMA (3,4-methylenedioxy-N-methylamphetamine). MBDB is metabolized and excreted similarly to MDMA: presumably, the majority of oral MBDB is excreted in urine unmetabolized.The main metabolic routes in man are thought to be O-dealkylation and subsequent(More)