Squamous cell cancer of the head and neck (SCCHN) is the sixth leading cause for cancer deaths worldwide. Despite extense knowledge of risk factors and pathogenesis about 50 percent of all patients and essentially every patient with metastatic SCCHN eventually die from this disease. We analyzed the clinical data and performed immunohistochemistry for… (More)
BACKGROUND Systemic treatment of head and neck squamous cell carcinoma (HNSCC) includes a variety of antineoplastic drugs. However, drug-resistance interferes with the effectiveness of chemotherapy. Preclinical testing models are needed in order to develop approaches to overcome chemoresistance. - METHODS Ten human cell lines were obtained from HNSCC,… (More)
BACKGROUND The checkpointkinase 2 (CHK2) is part of the highly conserved ATM-CHK2 signaling pathway, which is activated in response to DNA damage, in particular after double strand breaks which can be caused by carcinogens like smoking. After induction of downstream targets, e.g. the tumor suppressor p53, its activation leads to cell cycle arrest and… (More)
BACKGROUND Especially elderly and frail patients have a limited ability to compensate for side effects of a radical treatment of head and neck malignancies. Limiting the target volume to the macroscopic disease, without prophylactic nodal irradiation, might present a feasible approach for these patients. The present work therefore aims evaluating an… (More)
INTRODUCTION To understand if and which patients would be open-minded to Complementary and Alternative Medicine (CAM) use parallel to their oncological treatment. Moreover, we sought to determine which methods are most accepted and which are the primary motivators to use CAM. METHODS We developed and anonymously conducted a questionnaire for patients in… (More)
Objectives: Previous studies have shown the global burden of uncontrolled asthma, but similar studies have not been conducted speci cally for German asthma patients. e aim of the current study was to assess the impact of poor asthma control in German patients treated with ICS and LABA in free or xed-dose combination. Health and Wellness Survey (NHWS), an… (More)
A brief description of the anatomical relationship between the orbit and the paranasal sinus system is given. Sinus infections, celes, and tumors which can lead to orbital complications are described.