Henning Barthel

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Development of hypoxia-targeted therapies has stimulated the search for clinically applicable noninvasive markers of tumour hypoxia. Here, we describe the validation of [18F]fluoroetanidazole ([18F]FETA) as a tumour hypoxia marker by positron emission tomography (PET). Cellular transport and retention of [18F]FETA were determined in vitro under air vs(More)
The availability of a noninvasive method to detect and quantify apoptosis in tumours will enable tumour response to several cancer therapies to be assessed. We have synthesised two radiotracers, annexin V and the N-succinimidyl-3-iodobenzoic acid (SIB) derivative of annexin V, labelled with radio-iodine (124I and 125I) and provided proof of the concept by(More)
Software systems are an integral component of our everyday life as we find them in tools and embedded in equipment all around us. In order to ensure smooth, predictable, and accurate operation of these systems, it is crucial to produce and maintain systems that are highly reliable. A well-designed and well-maintained architecture goes a long way in(More)
Many software development organizations still lack support for obtaining intellectual control over their software development processes and for determining the performance of their processes and the quality of the produced products. Systematic support for detecting and reacting to critical process and product states in order to achieve planned goals is(More)
When presenting complex, multidimensional data to users, emphasis of relevant information plays an important role. Especially when data is arranged according to several criteria, the simultaneous use of multiple visualization metaphors frequently results in information overload and unintuitive visualizations. In this paper, we present a comparison of(More)
One of the main challenges in the maintenance of large-scale software systems is to ascertain the underlying software structure and to analyze its evolution. In this paper we present a tool to assist software architects and developers in not only understanding the software structure of their system but more importantly to track the insertion, removal, or(More)
Today, most visualization systems available on the market lack of flexibility regarding their visualization process with respect to either their interaction possibilities or their rendering quality. In order to satisfy individual user demands and to adapt to changing system loads and different hardware configurations, multi agent technology is combined with(More)
We provide computer-animated characters with haptic interaction, allowing human users to interfere with cognitive characters. Our work presents an interface between control and animation of virtual characters (CONTACT) and HapTEK, a framework for haptic interaction of a human hand with virtual reality (VR). This way, humancomputer interaction becomes truly(More)