Henk Vrijhof

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A list of 55 chemicals for which comprehensive rabbit eye irritation data were available was published by ECETOC in 1992. Similar data for a further 77 chemicals are now available. The total of chemicals included in the enlarged data bank is 132, assessed in 149 in vivo studies in rabbits. 28 of the chemicals were tested as solids, 24 as aqueous solutions.(More)
Although regulatory agencies formally encourage the integration of all available data in chemical risk assessment, consistent implementation of this practice has been constrained by the lack of a clear, systematic method for doing so. In this paper, we describe a methodology for evaluating, classifying and integrating human and animal data into the risk(More)
Fluorescence is the emission of radiation fol lowing absorption of radiation. In green plants chlorophyll emits red light after absorption of blue light. In vivo fluorescence primarily originates from chlorophyll a and is very weak: almost all of the absorbed energy is used for photosynthesis and converted to heat. Fluorescence can easily be measured by(More)
  • H Vrijhof
  • The Science of the total environment
  • 1985
A brief review is given of international agreements governing water pollution by hazardous organotin compounds. Emphasis is placed on the Rhine Chemical Convention (1976) and the Dangerous Substances Directive 76/464/EEC. Organotin pesticides first appeared in 1974 on the grey list. In 1976, however, the whole group of organotin compounds was placed on the(More)
In its evaluation, the task force examined the significance of aneuploidy in human disease, the methods for detecting aneugens, the mechanisms by which aneugens exert their action and how aneugens, as mutagens, are evaluated by regulatory authorities worldwide. Recommendations for the testing of aneugens and for risk characterisation of chemicals with(More)
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