Measures of gait and balance were undertaken in 11 elderly ambulant patients suffering from senile dementia of Alzheimer type of moderate severity, and in an equal number of healthy non-demented age- and sex-matched controls. Valid results were obtained in nine pairs. Compared with the controls the demented patients had significantly shorter step length,… (More)
Tumour necrosis factor inhibitor (TNFi) treatment in patients with rheumatoid arthritis is more effective when combined with methotrexate (MTX). 1–3 However, little is known about which MTX dose to use. With great interest, we read the article by Burmester et al 4 on the efficacy and safety of ascending MTX doses with adalimumab. This randomised… (More)
OBJECTIVES To study the number of patients that taper or discontinue concomitant methotrexate (MTX) in daily practice in patients with rheumatoid arthritis (RA) treated with tumour necrosis factor inhibitor (TNFi) and to analyse the effects of that adaption on disease activity and drug survival. METHODS Data were collected from the Dutch Rheumatoid… (More)
INTRODUCTION For patients with rheumatoid arthritis (RA) whose treatment with a tumour necrosis factor inhibitor (TNFi) is failing, several biological treatment options are available. Often, another TNFi or a biological with another mode of action is prescribed. The objective of this study was to compare the effectiveness and cost-effectiveness of three… (More)
The thermal distortion of the narrow face mold plates in a funnel-mold caster is explored with numerical simulation and online measurements. A three-dimensional finite-element model of the mold and waterbox with full geometric detail is used to explore the evolution of temperature and distortion of the mold during startup. The thermal boundary conditions… (More)
For patients with chronic pain conditions such as rheumatoid arthritis (RA), who experience elevated levels of distress, tailored-guided internet-based cognitive-behavioral treatment may be effective in improving psychological and physical functioning, and reducing the impact of RA on daily life. A multicenter, randomized controlled trial was conducted for… (More)
— Progress with silicon and silicon germanium based BiCMOS technologies over the past few years has been very impressive. Enabling the implementation of traditional microwave applications in silicon.
This paper describes a dual signal path (MIMO) low power, high performance direct conversion WiBro/WiMAX 802.16e radio transceiver optimized for mobile applications and coexistence with on-board cellular and WLAN/Bluetooth systems. It is fabricated in a SiGe BiCMOS process and achieves a receiver NF of less than 2.5 dB over an operation frequency of 2.3-2.7… (More)