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The hypothermic response to i.p. injection of ethanol (2.0-4.0 g/kg) in mice was found to be attenuated by a single equivalent ethanol injection given 24 hr earlier. The diminished hypothermic response was not an artifact since it could not be attributed to changes in body weight and was independent of familiarity with test environment and procedures. A(More)
Hypothermia was studied 5 min before, and 30 and 60 min after intraperitoneal administration of ethanol (3 g/kg) in 20 inbred strains of mice. Ethanol was given daily for 8 days, and temperatures were taken on Days 1, 3, 5, and 8. Tolerance was indexed by the reduction in hypothermia over days. There were large strain differences in baseline temperature,(More)
1. Hydralazine injected i.p. produced dosedependent hypothermia in mice and rats. 2. The hypothermic response to hydralazine was attenuated by a dose of the same drug given 24 h earlier. The attenuation could not be attributed to nonspecific experimental factors and indicates the development of tolerance. 3. Tolerance to hydralazine was dose-dependent and(More)
OBJECTIVE To compare waiting times for percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass graft (CABG) surgery in New York State, the Netherlands and Sweden and to determine whether queuing adversely affects patients' health. METHODS We reviewed the medical records of 4487 chronic stable angina patients who underwent PTCA or(More)
OBJECTIVES To identify appropriate screening conditions, stratified according to age and vulnerability, to prevent functional decline in older people. DESIGN A RAND/University of California at Los Angeles appropriateness method. SETTING The Netherlands. PARTICIPANTS A multidisciplinary panel of 11 experts. MEASUREMENTS The panelists assessed the(More)
These experiments investigated the effect of immediate posttrial administration of peripherally acting DL-4-hydroxyamphetamine on retention of a one-trial inhibitory avoidance response in intact, adrenal medullectomized, sympathectomized, and medullectomized and sympathectomized rats. In intact rats, 0.82 mg/kg of DL-4-OH-amphetamine enhanced retention(More)