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- Phyllis D Frosst, Henk J. Blom, +8 authors Ramona Rozen
- Nature Genetics
- 1995
Hyperhomocysteinaemia has been identified as a risk factor for cerebrovascular, peripheral vascular and coronary heart disease1–4. Elevated levels of plasma homocysteine can result from genetic or… (More)
- Nathalie M J van der Put, Fons J.M. Gabreëls, +5 authors Henk J. Blom
- American journal of human genetics
- 1998
Recently, we showed that homozygosity for the common 677(C-->T) mutation in the methylenetetrahydrofolate reductase (MTHFR) gene, causing thermolability of the enzyme, is a risk factor for… (More)
CONTEXT
In observational studies, individuals with elevated levels of plasma homocysteine tend to have moderately increased risk of coronary heart disease (CHD). The MTHFR 677C-->T polymorphism is a… (More)
- Rita Castro, I Robin Rivera, Henk J. Blom, Cornelis Jakobs, Isabel Tavares de Almeida
- Journal of Inherited Metabolic Disease
- 2006
Hyperhomocysteinaemia has been regarded as a new modifiable risk factor for atherosclerosis and vascular disease. Homocysteine is a branch-point intermediate of methionine metabolism, which can be… (More)
- Henk J. Blom, Gary M Shaw, Martin den Heijer, Richard H. Finnell
- Nature Reviews Neuroscience
- 2006
Neural tube closure takes place during early embryogenesis and requires interactions between genetic and environmental factors. Failure of neural tube closure is a common congenital malformation that… (More)
- Leo A. J. Kluijtmans, L. P. van den Heuvel, +7 authors Henk J. Blom
- American journal of human genetics
- 1996
Mild hyperhomocysteinemia is an established risk factor for cardiovascular disease. Genetic aberrations in the cystathionine beta-synthase (CBS) and methylenetetrahydrofolate reductase (MTHFR) genes… (More)
- Nathalie M J van der Put, Régine P M Steegers-Theunissen, +7 authors Henk J. Blom
- Lancet
- 1995
Periconceptional folate supplementation reduces the risk of neural-tube defects. We studied the frequency of the 677C-->T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene in 55… (More)
- J W Muntjewerff, René S. Kahn, Henk J. Blom, Martin den Heijer
- Molecular Psychiatry
- 2006
Elevated plasma homocysteine concentration has been suggested as a risk factor for schizophrenia, but the results of epidemiological studies have been inconsistent. The most extensively studied… (More)
- Mariska Davids, Joseph Dingbobga Tanyi Ndika, Gajja Sophi Salomons, Henk J. Blom, Tom Teerlink
- FEBS letters
- 2012
Low plasma homoarginine has emerged as a risk marker for cardiovascular disease. We exploited cells of a patient with a rare inborn error of metabolism to explore potential pathways of homoarginine… (More)
- Henk J. Blom, Yvo Michiel Smulders
- Journal of Inherited Metabolic Disease
- 2010
This overview addresses homocysteine and folate metabolism. Its functions and complexity are described, leading to explanations why disturbed homocysteine and folate metabolism is implicated in many… (More)