Henie M. J. Roelofs

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Infliximab-induced hepatotoxicity is reported in several case studies involving patients with inflammatory bowel disease (IBD) and a direct hepatotoxic effect has been proposed. The aim of this study was to determine the direct in vitro toxicity of infliximab. As a proof of principle the in vitro toxicity of thiopurines and methotrexate was also determined.(More)
of papers Abstracts of the posters 'Photobiological effects of 5-nitrofurfural in bacterial testsystems and irreversible photobinding' by R.W. Busker and G.M.J. Beijersbergen van Henegouwen, 'Photoproducts from chloramphenicol and their possible role in bone marrow toxicity', by H. de Vries, G.M.J. Beijersbergen van Henegouwen and H.C.G.M. Nooijens, and(More)
The effects of ethanol-feeding to rats, over a 6-week period, on the activation of genotoxic compounds of different chemical classes, requiring metabolic conversion to exert their mutagenic activity, were studied in isolated rat hepatocytes. The influence of such treatment on cytochrome P-450 content and N-acetylation in isolated hepatocytes was also(More)
Organized in honour of Prof. E.J. Ari~ns on the occasion of his retirement, by the Dutch Society of Pharmacology (Nederlandse Vereniging voor Farmacologie), the Division of Medicinal Chemistry of the Royal Dutch Chemical Society (Sectie Farmacochemie van de Koninklijke Nederlandse Chemische Vereniging), the Dutch Society of Clinical Pharmacology and(More)
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