Hengshan Wang

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Complexes of copper (II) with hesperetin, naringenin, and apigenin of general composition [CuL(2)(H(2)O)(2)] nH(2)O (1-3) have been synthesized and characterized by elemental analysis, UV-Vis, FT-IR, ESI-MS, and TG-DTG thermal analysis. The free ligands and the metal complexes have been tested in vitro against human cancer cell lines hepatocellular(More)
A series of dehydroabietic acid (DHAA) acyl-thiourea derivatives were designed and synthesized as potent antitumor agents. The in vitro pharmacological screening results revealed that the target compounds exhibited potent cytotoxicity against HeLa, SK-OV-3 and MGC-803 tumor cell lines, while they showed lower cytotoxicity against HL-7702 normal human river(More)
Recommender systems have become a popular technique and strategy for helping users select desirable products or services. Most research in this area focused on applying the method to help the customers in Business-to-Customer (B2C) electronic commerce (e-commerce), however, the participants in Business-to-Business (B2B) market can also get useful assistance(More)
BACKGROUND Alzheimer's disease (AD), a progressive and degenerative disorder, has become one of the severe problems among the aged population all over the world. To use cholinesterase inhibitor drugs has become the most predominant treatment strategy for AD. RESULTS A series of novel 1, 3-dihydroxyxanthone Mannich bases derivatives (1a ~ 4e) were(More)
In this study, chemical composition and antioxidant properties of Ocimum gratissimum (Og) were investigated. Leaves of Og were extracted using ethanol to obtain an ethanolic crude extract (ECE), and then ECE was sequentially partitioned with petroleum ether, ethyl acetate, n-butanol, and deionized water to give the corresponding petroleum ether fraction,(More)
Several hydroxyl Schiff base (HSB) compounds (1–10) with good radical scavenging activity (RSA) were designed. Compounds 6, 7, and 10 showed better RSAs than the common synthetic antioxidant 2,6-diter-butyl-4-methylphenol (BHT) in DPPH• and ABTS• assays. To probe whether these HSB compounds may exert their antioxidant effect through transition metal ion(More)
A series of novel coumarin-containing α-aminophosphonates with two chiral centers were synthesized and a single-crystal structure of compound 8g (8g′, (R)-diethyl ((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)(2-bromophenyl)methylphosphonate) was obtained. The in vitro antitumor activities of compound 8a–8g′ against human pulmonary carcinoma cell(More)
Several rhein-phosphonate derivatives (5a-c) were synthesized and evaluated for in vitro cytotoxicity against HepG-2, CNE, Spca-2, Hela and Hct-116 cell lines. Some compounds showed relatively high cytotoxicity. Especially compounds 5b exhibited the strongest cytotoxicity against HepG-2 and Spca-2 cells (IC50 was 8.82 and 9.01 µM), respectively. All the(More)
A series of novel coumarin-containing α-aminophosphonates were synthesized and evaluated for their antitumor activities against Human colorectal (HCT-116), human nasopharyngeal carcinoma (human KB) and human lung adenocarcinoma (MGC-803) cell lines in vitro. Compared with 7-hydroxy-4-methylcoumarin (4-MU), most of the derivatives showed an improved(More)