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The term "Web 2.0" is used to describe applications that distinguish themselves from previous generations of software by a number of principles. Existing work shows that Web 2.0 applications can be successfully exploited for technology-enhance learning. However, in-depth analyses of the relationship between Web 2.0 technology on the one hand and teaching(More)
The rat has been used extensively as a model for evaluating chemical toxicities and for understanding drug mechanisms. However, its transcriptome across multiple organs, or developmental stages, has not yet been reported. Here we show, as part of the SEQC consortium efforts, a comprehensive rat transcriptomic BodyMap created by performing RNA-Seq on 320(More)
Collaborative filtering as a classical method of information retrieval has been widely used in helping people to deal with information overload. In this paper, we introduce the concept of local user similarity and global user similarity, based on surprisal-based vector similarity and the application of the concept of maximin distance in graph theory.(More)
Since learning in Boltzmann machines is typically quite slow, there is a need to restrict connections within hidden layers. However, the resulting states of hidden units exhibit statistical dependencies. Based on this observation , we propose using l1/l2 regularization upon the activation probabilities of hidden units in restricted Boltzmann machines to(More)
Identifying new indications for existing drugs (drug repositioning) is an efficient way of maximizing their potential. Adverse drug reaction (ADR) is one of the leading causes of death among hospitalized patients. As both new indications and ADRs are caused by unexpected chemical-protein interactions on off-targets, it is reasonable to predict these(More)
We apply the spike-and-slab Restricted Boltzmann Machine (ssRBM) to texture modeling. The ssRBM with tiled-convolution weight sharing (TssRBM) achieves or surpasses the state-of-the-art on texture synthesis and inpainting by parametric models. We also develop a novel RBM model with a spike-and-slab visible layer and binary variables in the hidden layer.(More)
Serious adverse drug reactions (SADRs) are caused by unexpected drug-human protein interactions, and some polymorphisms within binding pockets make the population carrying these polymorphisms susceptible to SADR. Predicting which populations are likely to be susceptible to SADR will not only strengthen drug safety, but will also assist enterprises to adjust(More)
As major histocompatibility complexes in humans, the human leukocyte antigens (HLAs) have important functions to present antigen peptides onto T-cell receptors for immunological recognition and responses. Interpreting and predicting HLA-peptide binding are important to study T-cell epitopes, immune reactions, and the mechanisms of adverse drug reactions. We(More)
Due to a significant decline in the costs associated with next-generation sequencing, it has become possible to decipher the genetic architecture of a population by sequencing a large number of individuals to a deep coverage. The Korean Personal Genomes Project (KPGP) recently sequenced 35 Korean genomes at high coverage using the Illumina Hiseq platform(More)