Hendrik Niemann

Publications11
h-index10
Citations161
Highly Influential Citations7
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Sponge Derived Bromotyrosines: Structural Diversity through Natural Combinatorial Chemistry
TLDR
The Aplysina alkaloids finally provide a vivid example for dynamic wound induced bioconversions of natural products that generate highly efficient chemical weapons precisely when and where needed.
Anti-Biofilm Effect of Biodegradable Coatings Based on Hemibastadin Derivative in Marine Environment
TLDR
Results showed an evident efficiency of DBHB as compound and varnish to reduce the biofilm development, and the mode of action seems to be based principally on a perturbation of biofilm formation rather than on a biocidal activity in the tested conditions.
Trimeric hemibastadin congener from the marine sponge Ianthella basta.
TLDR
Among all the isolated compounds, the linear sesquibastadin 1 (1) and bastadin 3 (2) showed the strongest inhibition rates for at least 22 protein kinases and the macrocyclic bastadins demonstrated a strong cytotoxic potential against the murine lymphoma cell line L5178Y.
The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane
TLDR
The results suggest that PXA is a mitochondrial toxin with a novel mode of action that might prove a useful tool for the study of mitochondrial ion homoeostasis and membrane dynamics.
The Skeletal Amino Acid Composition of the Marine Demosponge Aplysina cavernicola
TLDR
The skeletal amino acid composition of the demosponge A. cavernicola is determined especially with respect to the presence of halogenated amino acids to imply that these yet unknown compounds are strongly, possibly covalently bound to the sponge skeletons.
Brominated Skeletal Components of the Marine Demosponges, Aplysina cavernicola and Ianthella basta: Analytical and Biochemical Investigations
TLDR
Quantitative potentiometric analyses confirm that the skeleton-associated bromine mainly withstands the MeOH-based extraction, which suggests that the respective, but yet unidentified, brominated compounds are strongly bound to the sponge skeletons, possibly by covalent bonding.
Cyclic versus Hemi-Bastadins. Pleiotropic Anti-Cancer Effects: from Apoptosis to Anti-Angiogenic and Anti-Migratory Effects
TLDR
The synthetically derived 5,5'-dibromohemibastadin-1 (DBHB) displayed not only in vitro growth inhibitory activity in cancer cells but also anti-angiogenic properties, enabling this compound to avoid plasmatic albumin binding through its direct delivery to the lungs to combat primary as well as secondary (metastases) tumors.
SAR of Sponge-Inspired Hemibastadin Congeners Inhibiting Blue Mussel PhenolOxidase
TLDR
This study suggests that natural selection has yielded structurally-optimized antifouling compounds that reveal superior enzyme inhibitory properties vs. congeners featuring structural moieties that are absent in the respective natural products.
Phomoxanthone A--From Mangrove Forests to Anticancer Therapy.
TLDR
The potent anti-tumour compound phomoxanthone A (PXA), which represents a tetrahydroxanthone atropisomer derived from the mangrove-associated fungus Phomopsis longicolla, was demonstrated to be due to an induction of caspase 3 dependent apoptosis.
Sponge-Inspired Dibromohemibastadin Prevents and Disrupts Bacterial Biofilms without Toxicity
TLDR
Dibromohemibastadin-1 (DBHB) is a promising AF molecule, leading to the inhibition of the activity of phenoloxidase, an enzyme involved in the attachment of mussels to surfaces and on bacterial adhesion and communication: quorum sensing.
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